Alginate-Based Microcapsules with a Molecule Recognition Linker and Photosensitizer for the Combined Cancer Treatment
文献类型：期刊论文
| 作者 | Du, Cuiling1; Zhao, Jie1; Fei, Jinbo1; Gao, Liang1; Cui, Wei1; Yang, Yang2; Li, Junbai1,2 |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2013-04-01 |
| 卷号 | 8期号:4页码:736-742 |
| 关键词 | Combined Therapy Drug Delivery Hydrogel Microcapsules Polysaccharide |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201201088 |
| 英文摘要 | A reactive template method was used to fabricate alginate-based hydrogel microcapsules. The uniform and well-dispersed hydrogel capsules have a high drug loading capacity. After they are coated by a folate-linked lipid mixture on the surface, the capsules possess higher cell uptake efficiency by the molecule recognition between folate and the folate-receptor overexpressed by the cancer cells. Moreover, in this bioconjugate, the lipid could remarkably reduce the release rate of hydrophilic doxorubicin from the hydrogel microcapsules and encapsulate the hydrophobic photosensitizer hypocrellin B. The biointerfaced capsules could be used as drug carriers for combined treatment against cancer cell proliferation in vitro; this was much more effective than chemotherapy or photodynamic therapy alone. |
| 语种 | 英语 |
| WOS记录号 | WOS:000316634200010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46449]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Cuiling,Zhao, Jie,Fei, Jinbo,et al. Alginate-Based Microcapsules with a Molecule Recognition Linker and Photosensitizer for the Combined Cancer Treatment[J]. CHEMISTRY-AN ASIAN JOURNAL,2013,8(4):736-742. |
| APA | Du, Cuiling.,Zhao, Jie.,Fei, Jinbo.,Gao, Liang.,Cui, Wei.,...&Li, Junbai.(2013).Alginate-Based Microcapsules with a Molecule Recognition Linker and Photosensitizer for the Combined Cancer Treatment.CHEMISTRY-AN ASIAN JOURNAL,8(4),736-742. |
| MLA | Du, Cuiling,et al."Alginate-Based Microcapsules with a Molecule Recognition Linker and Photosensitizer for the Combined Cancer Treatment".CHEMISTRY-AN ASIAN JOURNAL 8.4(2013):736-742. |
入库方式： OAI收割
来源：化学研究所
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