Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation
文献类型：期刊论文
| 作者 | Li, Bin1,2; Li, Taihang3; Chen, Gao1,2; Li, Xiaoyuan1; Yan, Lesan1,2; Xie, Zhigang1; Jing, Xiabin1; Huang, Yubin1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 13期号:7页码:893-902 |
| 关键词 | Biocompatibility Chain Sequences Hemoglobin Isoelectric Aggregation Micelles |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201300012 |
| 英文摘要 | Amphiphilic triblock copolymers with carbonyl groups located either in the middle segment or in the third side block are synthesized by adjusting feeding sequence of the comonomers. The conjugation of hemoglobin (Hb) on the copolymer micelles is realized by condensation reactions of carbonyl with the amino groups of Hb, and the gas-binding capacity of Hb is well preserved. Interestingly, the reassembly behavior of Hb-conjugated micelles (HbM) is explored by adjusting the pH. As for triblock copolymers with a carbonyl-functionalized segment as the third block, Hb is rearranged into the inner core of micelles when the pH is adjusted close to the isoelectric point of Hb. Therefore, it may provide a new needed route for fabrication of protein carriers, which is different from the traditional encapsulation technique. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327814500008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46535]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Taihang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Zhejiang Hisun Pharmaceut Co Ltd, Taizhou 318000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bin,Li, Taihang,Chen, Gao,et al. Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation[J]. MACROMOLECULAR BIOSCIENCE,2013,13(7):893-902. |
| APA | Li, Bin.,Li, Taihang.,Chen, Gao.,Li, Xiaoyuan.,Yan, Lesan.,...&Huang, Yubin.(2013).Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation.MACROMOLECULAR BIOSCIENCE,13(7),893-902. |
| MLA | Li, Bin,et al."Regulation of Conjugated Hemoglobin on Micelles through Copolymer Chain Sequences and the Protein's Isoelectric Aggregation".MACROMOLECULAR BIOSCIENCE 13.7(2013):893-902. |
入库方式： OAI收割
来源：化学研究所
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