Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation
文献类型：期刊论文
| 作者 | Hu, Xiuli1; Yan, Lesan1,2; Xiao, Haihua1,2; Li, Xiaoyuan1; Jing, Xiabin1 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2013-03-05 |
| 卷号 | 127期号:5页码:3365-3373 |
| 关键词 | Biodegradable Polyesters Functionalization Of Polymers Polymer-drug Conjugate Click Chemistry |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.37662 |
| 英文摘要 | The aim of this study is to develop azido-carrying biodegradable polymers and their postfunctionalization with alkynyl compounds via click chemistry and to investigate their potential use in drug delivery. Azido polymers were prepared by ring-opening polymerization of cyclic carbonate monomer, 2,2-bis(azidomethyl)trimethylene carbonate (ATC) with lactide using stannous octoate as catalyst. Several alkynyl compounds were selected to investigate the feasibility and reaction condition of click chemistry. With microwave-assisting, the reaction time of click chemistry was shortened to 5 min. By using poly(ethylene glycol) (PEG) as macroinitiator, amphiphilic block copolymer mPEG-b-P(LA-co-ATC) was obtained and it could self-assemble into micelles by solvent replacement method. The pendant groups were used for conjugating anticancer drugs gemcitabine and paclitaxel and fluorescent dye Rhodamine B. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide was used to assay the cytotoxicity of the conjugate micelles against SKOV-3 and HeLa cell lines. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 |
| 语种 | 英语 |
| WOS记录号 | WOS:000312936400011 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46645]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Xiuli,Yan, Lesan,Xiao, Haihua,et al. Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2013,127(5):3365-3373. |
| APA | Hu, Xiuli,Yan, Lesan,Xiao, Haihua,Li, Xiaoyuan,&Jing, Xiabin.(2013).Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation.JOURNAL OF APPLIED POLYMER SCIENCE,127(5),3365-3373. |
| MLA | Hu, Xiuli,et al."Application of microwave-assisted click chemistry in the preparation of functionalized copolymers for drug conjugation".JOURNAL OF APPLIED POLYMER SCIENCE 127.5(2013):3365-3373. |
入库方式： OAI收割
来源：化学研究所
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