A cross-linked polymeric micellar delivery system for cisplatin(IV) complex
文献类型：期刊论文
| 作者 | Song, Haiqin1; Wang, Rui2,3; Xiao, Haihua2,3; Cai, Haidong4; Zhang, Wenjing4; Xie, Zhigang2; Huang, Yubin2; Jing, Xiabin2; Liu, Tongjun1 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
 |
| 出版日期 | 2013 |
| 卷号 | 83期号:1页码:63-75 |
| 关键词 | Cell Uptake Cisplatin Intracellular Reduction Polymer-drug Conjugates Prodrug |
| ISSN号 | 0939-6411 |
| DOI | 10.1016/j.ejpb.2012.09.004 |
| 英文摘要 | A polymeric cisplatin(IV) prodrug in the form of cross-linked micelles (M(Pt(IV)) was prepared by first constructing MPEG-b-PCL-b-PLL micelles and then attaching a cisplatin(IV) complex with two axial succinic moieties to the lysine residues of the carrier polymer in aqueous medium. The micelles obtained were characterized by TEM, DLS, and zeta potential measurement. Their in vitro release experiments were carried out at pH 7.4 and 5.0 or in the presence of 5 mM sodium ascorbate (NaAsc). Results showed that the micelles were sensitive to both acidic hydrolysis and mild reducing agents; in the presence of 5 mM NaAsc, cisplatin(II) was directly released and the released cisplatin(II) could chelate with nucleobases; the micelles displayed comparable cytotoxicities to cisplatin; and the micelles were much more efficiently internalized by the cells than cisplatin(II) and cisplatin(IV) counterparts. Moreover, in vivo study showed accumulation of more Pt species in the tumor site and lower systematic toxicity compared to free cisplatin(II) and cisplatin(IV). This polymeric prodrug of cisplatin is expected to be used more for future study and applications. (c) 2012 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315305800008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46665]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Jilin Univ, Dept Colorectal & Anal Surg, China Japan Union Hosp, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Changchun Univ Sci & Technol, Dept Chem & Environm Engn, Changchun, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Haiqin,Wang, Rui,Xiao, Haihua,et al. A cross-linked polymeric micellar delivery system for cisplatin(IV) complex[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2013,83(1):63-75. |
| APA | Song, Haiqin.,Wang, Rui.,Xiao, Haihua.,Cai, Haidong.,Zhang, Wenjing.,...&Liu, Tongjun.(2013).A cross-linked polymeric micellar delivery system for cisplatin(IV) complex.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,83(1),63-75. |
| MLA | Song, Haiqin,et al."A cross-linked polymeric micellar delivery system for cisplatin(IV) complex".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 83.1(2013):63-75. |
入库方式： OAI收割
来源：化学研究所
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