Preparation and Optical Property of New Fluorescent Nanoparticles
文献类型：期刊论文
| 作者 | Chong, Hui; Zhu, Chunlei; Song, Jinzhao; Feng, Liheng; Yang, Qiong; Liu, Libing; Lv, Fengting; Wang, Shu |
| 刊名 | MACROMOLECULAR RAPID COMMUNICATIONS
 |
| 出版日期 | 2013-05-14 |
| 卷号 | 34期号:9页码:736-742 |
| ISSN号 | 1022-1336 |
| 关键词 | Anticancer Cell Migration Fluorescent Imaging Light Irradiation Nanoparticles |
| DOI | 10.1002/marc.201200755 |
| 英文摘要 | A new fluorescent nanoparticle (PIOT-HA) is synthesized with cationic polyester (PIOT) and anionic hyaluronic acid (HA) by electrostatic interactions in an aqueous solution. The nanoparticles (NPs) are degradable upon treatments with alkali or hyaluronidase, which exhibits better biological safety and potential application in vitro and in vivo. Through specific interactions between the HA locating on the surfaces of PIOT-HA NPs and the CD44 protein over-expressed on the MDA-MB-231 cancer cell line, PIOT-HA NPs could selectively image the cancer cells. Upon white light irradiation, the PIOT-HA NPs can sensitize oxygen to generate reactive oxygen species (ROS) that inactivate the neighboring CD44 protein, which inhibits the migration of MDA-MB-231 cancer cells. |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000318354500006 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46671]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Qiong |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chong, Hui,Zhu, Chunlei,Song, Jinzhao,et al. Preparation and Optical Property of New Fluorescent Nanoparticles[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2013,34(9):736-742. |
| APA | Chong, Hui.,Zhu, Chunlei.,Song, Jinzhao.,Feng, Liheng.,Yang, Qiong.,...&Wang, Shu.(2013).Preparation and Optical Property of New Fluorescent Nanoparticles.MACROMOLECULAR RAPID COMMUNICATIONS,34(9),736-742. |
| MLA | Chong, Hui,et al."Preparation and Optical Property of New Fluorescent Nanoparticles".MACROMOLECULAR RAPID COMMUNICATIONS 34.9(2013):736-742. |
入库方式： OAI收割
来源：化学研究所
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