Plasma Proteins Adsorption Mechanism on Polyethylene-Grafted Poly(ethylene glycol) Surface by Quartz Crystal Microbalance with Dissipation
文献类型：期刊论文
| 作者 | Jin, Jing1; Jiang, Wei1; Yin, Jinghua1; Ji, Xiangling1; Stagnaro, Paola2 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2013-06-04 |
| 卷号 | 29期号:22页码:6624-6633 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/la4017239 |
| 英文摘要 | Protein adsorption has a vital role in biomaterial surface science because it is directly related to the hemocompatibility of blood-contacting materials. In this study, monomethoxy poly(ethylene glycol) (mPEG) with two different molecular weights was grafted on polyethylene as a model to elucidate the adsorption mechanisms of plasma protein through quartz crystal microbalance with dissipation (QCM-D). Combined with data from platelet adhesion, whole blood clotting time, and hemolysis rate, the blood compatibility of PE-g-mPEG film was found to have significantly improved. Two adsorption schemes were developed for real-time monitoring of protein adsorption. Results showed that the preadsorbed bovine serum albumin (BSA) on the surfaces of PE-g-mPEG films could effectively inhibit subsequent adsorption of fibrinogen (Fib). Nonspecific protein adsorption of BSA was determined by surface coverage, not by the chain length of PEG. Dense PEG brush could release more trapped water molecules to resist BSA adsorption. Moreover, the preadsorbed Fib could be gradually displaced by high-concentration BSA. However, the adsorption and displacement of Fib was determined by surface hydrophilicity. |
| 语种 | 英语 |
| WOS记录号 | WOS:000320097000014 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46679]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jiang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.CNR, Ist Studio Macromol, I-16149 Genoa, Italy |
| 推荐引用方式 GB/T 7714 | Jin, Jing,Jiang, Wei,Yin, Jinghua,et al. Plasma Proteins Adsorption Mechanism on Polyethylene-Grafted Poly(ethylene glycol) Surface by Quartz Crystal Microbalance with Dissipation[J]. LANGMUIR,2013,29(22):6624-6633. |
| APA | Jin, Jing,Jiang, Wei,Yin, Jinghua,Ji, Xiangling,&Stagnaro, Paola.(2013).Plasma Proteins Adsorption Mechanism on Polyethylene-Grafted Poly(ethylene glycol) Surface by Quartz Crystal Microbalance with Dissipation.LANGMUIR,29(22),6624-6633. |
| MLA | Jin, Jing,et al."Plasma Proteins Adsorption Mechanism on Polyethylene-Grafted Poly(ethylene glycol) Surface by Quartz Crystal Microbalance with Dissipation".LANGMUIR 29.22(2013):6624-6633. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。