TAT-Modified Mixed Micelles as Biodegradable Targeting and Delivering System for Cancer Therapeutics
文献类型：期刊论文
| 作者 | Li, Xiaoyuan1; Wang, Mingzhe1; Liu, Changbai2; Jing, Xiabin1; Huang, Yubin1 |
| 刊名 | JOURNAL OF APPLIED POLYMER SCIENCE
 |
| 出版日期 | 2013-12-15 |
| 卷号 | 130期号:6页码:4598-4607 |
| 关键词 | Biodegradable Drug Delivery Systems Micelles |
| ISSN号 | 0021-8995 |
| DOI | 10.1002/app.39744 |
| 英文摘要 | A mixed micellar system of novel function was designed and synthesized by co-assembling TAT (cell penetrating peptide)-modified poly (ethylene glycol)-poly(l-lactide) (PEG-PLA) copolymer with the drug-conjugated poly(ethylene glycol)-b-poly(l-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (mPEG-b-P(LA-co-MCC)) copolymer. UV-Vis, Matrix-assisted laser desorption/ionization time-of-flight, and XPS were used to ensure the successful modification of the copolymers with TAT and anti-tumor drugs. The size of spherical nanomicelles increased from 50 to 60 nm as of empty polymeric micelles to 100-150 nm as of drug-loaded ones, determined by dynamic light scattering and TEM. Daunorubicin was selected as model drug for in vitro evaluations on different cell lines. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay clearly indicated an improved cell growth inhibition of the TAT-modified mixed micelles. While green fluorescent protein was used as a marker for the mixed micelle, small amount of DMSO was necessary to enhance the accumulation of the mixed micelles in cell lines Caski. Mediated by TAT, mixed micelles containing Apoptin (a tumor-specific apoptosis drug) showed higher level of tumor cell internalization and growth inhibition than that of mixed micelles without TAT modification. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4598-4607, 2013 |
| 语种 | 英语 |
| WOS记录号 | WOS:000329153300089 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46689]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Huang, Yubin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Three Gorges Univ, Inst Mol Biol, Yichang 443002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaoyuan,Wang, Mingzhe,Liu, Changbai,et al. TAT-Modified Mixed Micelles as Biodegradable Targeting and Delivering System for Cancer Therapeutics[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2013,130(6):4598-4607. |
| APA | Li, Xiaoyuan,Wang, Mingzhe,Liu, Changbai,Jing, Xiabin,&Huang, Yubin.(2013).TAT-Modified Mixed Micelles as Biodegradable Targeting and Delivering System for Cancer Therapeutics.JOURNAL OF APPLIED POLYMER SCIENCE,130(6),4598-4607. |
| MLA | Li, Xiaoyuan,et al."TAT-Modified Mixed Micelles as Biodegradable Targeting and Delivering System for Cancer Therapeutics".JOURNAL OF APPLIED POLYMER SCIENCE 130.6(2013):4598-4607. |
入库方式： OAI收割
来源：化学研究所
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