pH-Responsive Drug Delivery by Amphiphilic Copolymer through BoronateCatechol Complexation
文献类型：期刊论文
| 作者 | Wu, Suhong1; Qi, Ruogu1; Kuang, Huihui1; Wei, Yen2; Jing, Xiabin1; Meng, Fanbo3; Huang, Yubin1 |
| 刊名 | CHEMPLUSCHEM
 |
| 出版日期 | 2013-02-01 |
| 卷号 | 78期号:2页码:175-184 |
| 关键词 | Antitumor Agents Block Copolymers Drug Delivery Nanoparticles Ph Response |
| ISSN号 | 2192-6506 |
| DOI | 10.1002/cplu.201200227 |
| 英文摘要 | Stimuli-responsive micellar nanoparticles are gaining considerable attention in the field of drug delivery because of their great advantages of high efficiency in tumor accumulation through the enhanced permeability and retention effect and rapid drug release. In this study, a novel catechol moiety-containing amphiphilic, biodegradable polymeric carrier, monomethoxy poly(ethylene glycol)-block-poly(epsilon-caprolactone)-block-poly(L-lysine)-graft-[3-(3,4-dihydroxyphenyl)propionic acid], was employed for delivery of the anticancer drug bortezomib (BTZ) to cancer cells. The strategy is based on the facile conjugation of BTZ to catechol-containing polymeric carriers through boronate formation, which could dissociate in acidic environments to liberate its payload BTZ to inhibit proteasome function. This reducing BTZcatechol interaction with decreasing pHvalue was demonstrated by microcalorimetry analysis using isothermal titration calorimetry. Notably, the obtained micellar BTZ complex that self-assembled from drug-loaded amphiphilic polymer was internalized effectively by MCF-7 breast cancer cells and resulted in significant 26Sproteasome inhibition. Furthermore, the micellar BTZ complex induced remarkable apoptosis on MCF-7 and HeLa cancer cells and exhibited little toxicity on HEK293 normal cells. More importantly, systemic delivery of micellar BTZ complex prolonged its blood circulation and resulted in significant accumulation in the tumor site relative to free drug, thus suggesting therapeutic promise for micellar BTZ delivery in cancer therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315117100007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46747]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Meng, Fanbo |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Jilin Univ, Dept Cardiol, China Japan Union Hosp, Changchun 130033, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Suhong,Qi, Ruogu,Kuang, Huihui,et al. pH-Responsive Drug Delivery by Amphiphilic Copolymer through BoronateCatechol Complexation[J]. CHEMPLUSCHEM,2013,78(2):175-184. |
| APA | Wu, Suhong.,Qi, Ruogu.,Kuang, Huihui.,Wei, Yen.,Jing, Xiabin.,...&Huang, Yubin.(2013).pH-Responsive Drug Delivery by Amphiphilic Copolymer through BoronateCatechol Complexation.CHEMPLUSCHEM,78(2),175-184. |
| MLA | Wu, Suhong,et al."pH-Responsive Drug Delivery by Amphiphilic Copolymer through BoronateCatechol Complexation".CHEMPLUSCHEM 78.2(2013):175-184. |
入库方式： OAI收割
来源：化学研究所
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