Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice
文献类型：期刊论文
| 作者 | Ma, Jinshu1; Liu, Zhenning2; Wang, Fang1; Zhou, Qinghai3; Feng, Chao4; Li, Fan1 |
| 刊名 | JOURNAL OF BIONIC ENGINEERING
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 10期号:4页码:514-521 |
| 关键词 | Biomaterial Poly-propylene Carbonate Ppc Biodistribution |
| ISSN号 | 1672-6529 |
| DOI | 10.1016/S1672-6529(13)60245-0 |
| 英文摘要 | Biomaterials have attracted more attention from biomedical research in recent years. Yet there are still unmet demands for current biomaterials, such as the reduction of local inflammation of the implantation site. Poly-Propylene Carbonate (PPC), a polymer with ester bonds on CO2 backbone, degrades to CO2 and water, which are natural components of human body, yielding less inflammatory response than traditional biomaterials. However, the tensile strength and heat resistance properties of PPC are less ideal. In order to improve the properties of PPC, we have developed a new PPC (M-PPC), modified by mixing with Poly-3-Hydroxybutyrate (PIM). Here, we report the biodistribution profiles of PPC and M-PPC, their biocompatibility arid toxicity. I-125-radiolabeled PPC and M-PPC were prepared and their biodistribution in Balb/c mice were investigated. Then acute systemic toxicity and haemolysis assays were conducted to study their toxicity and biocompatibility 'respectively. Results show that M-PPC has a good potential to be used as bone repair materials because it possesses typical biodistribution pattern in major organs, minimal toxicity and good biocompatibility. |
| 语种 | 英语 |
| WOS记录号 | WOS:000326358700013 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46869]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Fan |
| 作者单位 | 1.Jilin Univ, Norman Bethune Coll Med, Dept Pathogenobiol, Changchun 130021, Peoples R China 2.Jilin Univ, Key Lab Bion Engn, Minist Educ, Changchun 130022, Peoples R China 3.Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 4.Jilin Univ, Hosp 1, Dept Neurol, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Jinshu,Liu, Zhenning,Wang, Fang,et al. Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice[J]. JOURNAL OF BIONIC ENGINEERING,2013,10(4):514-521. |
| APA | Ma, Jinshu,Liu, Zhenning,Wang, Fang,Zhou, Qinghai,Feng, Chao,&Li, Fan.(2013).Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice.JOURNAL OF BIONIC ENGINEERING,10(4),514-521. |
| MLA | Ma, Jinshu,et al."Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice".JOURNAL OF BIONIC ENGINEERING 10.4(2013):514-521. |
入库方式： OAI收割
来源：化学研究所
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