Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress
文献类型：期刊论文
| 作者 | Chen, Bo; Jia, Yi; Zhao, Jie; Li, Hong; Dong, Weiguang; Li, Junbai |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY C
 |
| 出版日期 | 2013-09-26 |
| 卷号 | 117期号:38页码:19751-19758 |
| ISSN号 | 1932-7447 |
| DOI | 10.1021/jp407164q |
| 英文摘要 | Hemoglobin-based nanotubes for the treatment of oxidative stress are successfully fabricated via covalent layer-by-layer assembly. Catalase, the most efficient enzyme for scavenging the hydrogen peroxide (H2O2), is embedded into the inner pores of the hemoglobin/dialdehyde heparin (Hb/DHP)(5) nanotubes via covalent bonding to protect the delicate enzyme from inactivation after the removal of the polycarbonate (PC) template. Dialdehyde heparin (DHP) as wall components is a cross-linker. The biocompatibility and capabilities of the nanotubes to protect the cells under oxidative stress are characterized with the Cell Counting Kit-8 (CCK-8). The scavenging capabilities of four kinds of autofluorescent nanotubes are tested through the reaction with H2O2 by the measurement of the UV-vis absorbance at 240 nm. All the experimental results show that the assembled hemoglobin-based nanotubes possess H2O2-scavenging capacity as well as biocompatibility, indicating the potential application in the treatment of oxidative stress. |
| 语种 | 英语 |
| WOS记录号 | WOS:000330162500057 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46911]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Bo,Jia, Yi,Zhao, Jie,et al. Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2013,117(38):19751-19758. |
| APA | Chen, Bo,Jia, Yi,Zhao, Jie,Li, Hong,Dong, Weiguang,&Li, Junbai.(2013).Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress.JOURNAL OF PHYSICAL CHEMISTRY C,117(38),19751-19758. |
| MLA | Chen, Bo,et al."Assembled Hemoglobin and Catalase Nanotubes for the Treatment of Oxidative Stress".JOURNAL OF PHYSICAL CHEMISTRY C 117.38(2013):19751-19758. |
入库方式： OAI收割
来源：化学研究所
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