Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers
文献类型：期刊论文
| 作者 | Du, Cuiling; Zhao, Jie; Fei, Jinbo; Cui, Yue; Li, Junbai |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2013-09-01 |
| 卷号 | 2期号:9页码:1246-1251 |
| 关键词 | Anticancer Drug Microcapsule Molecular Assembly Drug Delivery Doxorubicin |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201200414 |
| 英文摘要 | Doxorubicin, together with the modified polysaccharide (alginate dialdehyde), was used as a wall material to fabricate microcapsules through self-cross-linking by a template method. The microcapsules as-prepared are pH-responsive. Relevant scanning electronic microscopy, atom force microscopy and confocal laser scanning microscopy confirm the morphology of the uniform microcapsules. The spectroscopic results show that the microcapsules are assembled through electrostatic interaction and Schiff's base covalent bonding. Doxorubicin can be released sustainably from the capsules in buffer solution at a lower pH value. The cellular uptake of the microcapsules and drug release induced by acidic microenvironment are time-dependent processes. The cell cytotoxicity experiments in vitro demonstrate that the doxorubicin-based microcapsules have high efficiency to kill the cancer cells. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327821300010 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/46953]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Cuiling,Zhao, Jie,Fei, Jinbo,et al. Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers[J]. ADVANCED HEALTHCARE MATERIALS,2013,2(9):1246-1251. |
| APA | Du, Cuiling,Zhao, Jie,Fei, Jinbo,Cui, Yue,&Li, Junbai.(2013).Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers.ADVANCED HEALTHCARE MATERIALS,2(9),1246-1251. |
| MLA | Du, Cuiling,et al."Assembled Microcapsules by Doxorubicin and Polysaccharide as High Effective Anticancer Drug Carriers".ADVANCED HEALTHCARE MATERIALS 2.9(2013):1246-1251. |
入库方式： OAI收割
来源：化学研究所
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