Stimuli responsive deswelling of radiation synthesized collagen hydrogel in simulated physiological environment
文献类型：期刊论文
| 作者 | Zhang, Xiangmei1,2; Xu, Ling1,2,3; Wei, Shicheng2,4; Zhai, Maolin5; Li, Jiuqiang5 |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 101期号:8页码:2191-2201 |
| 关键词 | Collagen Hydrogel Radiation Crosslinking Environmental Stimuli Response Tissue Scaffold |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.34525 |
| 英文摘要 | Collagen hydrogels were prepared via radiation crosslinking. The simulated physiological environmental effects related to their biomedical applications on the volume phase transition of collagen hydrogel were studied, that is stimuli response to ions, temperature, and pH. The deswelling behavior of collagen hydrogel depends on the salt concentration, temperature, pH, and the hydrogel preparation procedure. Meanwhile, hydrogel structure related to the volume phase transition was investigated by FTIR, fluorescence spectrum, and HR-MAS NMR. Deswelling in salt solution caused little change on collagen conformation, and a denser network led to more significant tyrosine-derived fluorescence quenching. Hydrogen bonding between hydrated water and collagen polypeptide chain was dissociated and the activity of hydrophobic side chain increased, inducing a higher extent of contraction with the increasing of salt concentration. Moreover, salt solution treatments weakened the electrostatic interactions, side chains interactions, and hydrogen bonding of collagen hydrogel, which reduced the thermal stability of collagen hydrogel. Comparing with cell-free collagen hydrogel contraction, fibroblasts did not aggravate contraction of collagen hydrogel significantly. This study elucidated the deswelling mechanism of radiation crosslinked collagen hydrogel in simulated physiological environment and provides strategies for controlling the stimuli response of collagen hydrogel in biomedical application. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013. |
| 语种 | 英语 |
| WOS记录号 | WOS:000320778000006 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47011]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, Ling |
| 作者单位 | 1.Peking Univ, Coll Engn, Beijing Key Lab Solid Waste Utilizat & Management, Beijing 100871, Peoples R China 2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China 3.Peking Univ, Shenzhen Inst, Shenzhen Key Lab Polymer Sci, Shenzhen 518057, Peoples R China 4.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China 5.Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiangmei,Xu, Ling,Wei, Shicheng,et al. Stimuli responsive deswelling of radiation synthesized collagen hydrogel in simulated physiological environment[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2013,101(8):2191-2201. |
| APA | Zhang, Xiangmei,Xu, Ling,Wei, Shicheng,Zhai, Maolin,&Li, Jiuqiang.(2013).Stimuli responsive deswelling of radiation synthesized collagen hydrogel in simulated physiological environment.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,101(8),2191-2201. |
| MLA | Zhang, Xiangmei,et al."Stimuli responsive deswelling of radiation synthesized collagen hydrogel in simulated physiological environment".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 101.8(2013):2191-2201. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。