Thymine Modified Amphiphilic Biodegradable Copolymers for Photo-Cross-Linked Micelles as Stable Drug Carriers
文献类型：期刊论文
| 作者 | Kuang, Huihui1,2; He, Hongyan1,2; Hou, Jie3; Xie, Zhigang1; Jing, Xiabin1; Huang, Yubin1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 13期号:11页码:1593-1600 |
| 关键词 | Amphiphilic Copolymers Degradable Drug Delivery Photo-cross-linking Thymine |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201300254 |
| 英文摘要 | A photo-cross-linked micelle is synthesized via photodimerization of thymine moieties fabricated from amphiphilic block copolymers (mPEG-b-P(LA-co-MPT). The crosslinking behavior is monitored by UV-Vis spectra and H-1 NMR. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that cross-linked micelles had smaller sizes than their uncross-linked precursors. In vitro studies reveal that cross-linking of the micelle cores results in a slow drug release and faster cellular uptake in comparison with uncross-linked ones in MCF-7 and Hela cells. Moreover, the paclitaxel (PTX)-loaded core-cross-linked micelles exhibit similar anticancer efficacy as free PTX. This work provides a convenient tool for designing a more stable structure in the blood circulation to realize a controlled drug delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000328320300012 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47081]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Huang, Yubin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Jia Mu Si Univ, Hosp 1, Jiamusi 154002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Huihui,He, Hongyan,Hou, Jie,et al. Thymine Modified Amphiphilic Biodegradable Copolymers for Photo-Cross-Linked Micelles as Stable Drug Carriers[J]. MACROMOLECULAR BIOSCIENCE,2013,13(11):1593-1600. |
| APA | Kuang, Huihui,He, Hongyan,Hou, Jie,Xie, Zhigang,Jing, Xiabin,&Huang, Yubin.(2013).Thymine Modified Amphiphilic Biodegradable Copolymers for Photo-Cross-Linked Micelles as Stable Drug Carriers.MACROMOLECULAR BIOSCIENCE,13(11),1593-1600. |
| MLA | Kuang, Huihui,et al."Thymine Modified Amphiphilic Biodegradable Copolymers for Photo-Cross-Linked Micelles as Stable Drug Carriers".MACROMOLECULAR BIOSCIENCE 13.11(2013):1593-1600. |
入库方式： OAI收割
来源：化学研究所
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