Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers
文献类型：期刊论文
| 作者 | Duan, Li2; Yan, Xuehai3; Wang, Anhe1; Jia, Yi1; Li, Junbai1 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2012-08-01 |
| 卷号 | 6期号:8页码:6897-6904 |
| 关键词 | Hemoglobin Spheres Porous Caco3 Lbl Assembly High Loading Artificial Oxygen Carriers |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/nn301735u |
| 英文摘要 | Seeking safe and effective artificial blood substitutes based on hemoglobin (Hb) as oxygen carriers is an important topic. A significant challenge is to enhance the loading content of Hb in a well-defined structure. Here we report a facile and controllable avenue to fabricate Hb spheres with a high loading content by templating decomposable porous CaCO3 particles in collaboration with covalent layer-by-layer assembly technique. The surface of the Hb spheres was further chemically modified by biocompatible polyethylene glycol to protect and stabilize the system. Multiple characterization techniques were employed to reveal the loading and density of Hb in an individual CaCO3 particle. The results demonstrate that the strategy developed In this work is effective and flexible for construction of the highly loaded Hb spheres. More importantly, such Hb spheres retain their carrying-releasing oxygen function. It may thus have great potential to develop Hb spheres with highly loaded content as realistic artificial blood substitutes in the future. |
| 语种 | 英语 |
| WOS记录号 | WOS:000307988900043 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47213]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS, Beijing 100190, Peoples R China 2.NW Inst Nucl Technol, Xian 710024, Shaanxi, Peoples R China 3.Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany |
| 推荐引用方式 GB/T 7714 | Duan, Li,Yan, Xuehai,Wang, Anhe,et al. Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers[J]. ACS NANO,2012,6(8):6897-6904. |
| APA | Duan, Li,Yan, Xuehai,Wang, Anhe,Jia, Yi,&Li, Junbai.(2012).Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers.ACS NANO,6(8),6897-6904. |
| MLA | Duan, Li,et al."Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers".ACS NANO 6.8(2012):6897-6904. |
入库方式： OAI收割
来源：化学研究所
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