Protein-Protein Interaction: Prediction, Design, and Modulation
文献类型：期刊论文
| 作者 | Zhang Chang-Sheng1,2,3; Lai Lu-Hua1,2,3 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 28期号:10页码:2363-2380 |
| 关键词 | Protein-protein Interaction Interaction Prediction Protein-protein Docking Protein-protein Interaction Design Protein Drug Drug Design |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/PKU.WHXB201209172 |
| 英文摘要 | Protein-protein interactions are the essential events in life at the molecular level. The three-dimensional structures of protein-protein interactions provide clear pictures for the molecular details of various cellular processes. Understanding the basics of protein-protein interaction provides clues for revealing the secret of life, and useful information for designing proteins for various application purposes. The present review summarizes recent progresses of protein-protein interaction prediction, design, and modulation study, briefly introduces the progresses in the authors' group, and discusses future directions of the field. Protein-protein interaction network analysis, protein-protein interaction principles, and computational analysis of interfaces are briefly reviewed first. Methods and progress for predicting protein-protein interaction at sequence level, interaction-site level, and complex-structure level are given. Based on the knowledge about the nature of protein-protein interactions, protein-protein interaction design and modulation can be done on purpose. We give a summary of three kinds of protein-protein interaction design methods: redesign, grafting, and de novo, and three kinds of protein-protein interaction modulation methods using small molecules: direct competition, allosteric modulation, and stabilization. Protein design approaches for potential therapeutic applications targeting protein-protein interactions are also discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000310181300018 |
| 出版者 | PEKING UNIV PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47235]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lai Lu-Hua |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Inst Phys Chem, Beijing Natl Lab Mol Sci,State Key Lab Struct Che, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Quantitat Biol, Beijing 100871, Peoples R China 3.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Chang-Sheng,Lai Lu-Hua. Protein-Protein Interaction: Prediction, Design, and Modulation[J]. ACTA PHYSICO-CHIMICA SINICA,2012,28(10):2363-2380. |
| APA | Zhang Chang-Sheng,&Lai Lu-Hua.(2012).Protein-Protein Interaction: Prediction, Design, and Modulation.ACTA PHYSICO-CHIMICA SINICA,28(10),2363-2380. |
| MLA | Zhang Chang-Sheng,et al."Protein-Protein Interaction: Prediction, Design, and Modulation".ACTA PHYSICO-CHIMICA SINICA 28.10(2012):2363-2380. |
入库方式： OAI收割
来源：化学研究所
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