Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation
文献类型：期刊论文
| 作者 | Yang, Qiong1; Dong, Ying2; Wu, Wei1; Zhu, Chunlei1; Chong, Hui1; Lu, Jiangyang2; Yu, Dehai1; Liu, Libing1; Lv, Fengting1; Wang, Shu1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 3 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms2209 |
| 英文摘要 | Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based fluorescence resonance energy transfer to quantitatively analyse DNA methylation levels of seven colon cancer-related genes in a Chinese population. Through a stepwise discriminant analysis and cumulative detection of methylation alterations, we acquire high accuracy and sensitivity for colon cancer detection (86.3 and 86.7%) and for differential diagnosis (97.5 and 94%). Moreover, we identify a correlation between the CpG island methylator phenotype and clinically important parameters in patients with colon cancer. The cumulative analysis of promoter methylation alterations by the cationic conjugated polymer-based fluorescence resonance energy transfer may be useful for the screening and differential diagnosis of patients with colon cancer, and for performing clinical correlation analyses. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315992100041 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47253]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Lu, Jiangyang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army, Gen Hosp, Affiliated Hosp 1, Beijing 100037, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Qiong,Dong, Ying,Wu, Wei,et al. Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation[J]. NATURE COMMUNICATIONS,2012,3. |
| APA | Yang, Qiong.,Dong, Ying.,Wu, Wei.,Zhu, Chunlei.,Chong, Hui.,...&Wang, Shu.(2012).Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation.NATURE COMMUNICATIONS,3. |
| MLA | Yang, Qiong,et al."Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation".NATURE COMMUNICATIONS 3(2012). |
入库方式： OAI收割
来源：化学研究所
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