Reactive Polymer as a Versatile Toolbox for Construction of Multifunctional Superparamagnetic Nanocomposites
文献类型：期刊论文
| 作者 | Shen, Ying1,2; Zhao, Lingzhi1,2; Qi, Li1; Qiao, Juan1; Mao, Lanqun1; Chen, Yi1 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 18期号:43页码:13755-13761 |
| 关键词 | Cell Recognition Fluorescent Probes Magnetic Nanocomposites Magnetic Properties Nanostructures Nanotechnology Reactive Polymers Transferrin |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.201201993 |
| 英文摘要 | The development of magnetic nanoparticles with multiple functions has been an ever-growing field because of their diverse applications in drug delivery, biosensing, cell labeling, and so on. In this study, a facile method was developed to construct multifunctional magnetic nanocomposites. The approach is based on the use of poly(glycidyl methacrylate), PGMA, with numerous epoxy groups as reactive polymer to combine with fluorescent dye, the surface of magnetic nanoparticles, and targeting ligands directly without expatiatory functionality design. The resultant nanocomposites with good superparamagnetic and fluorescent properties could be exploited for bioimaging. Moreover, after conjugation with a model protein, namely, transferrin, which specifically targets cells overexpressing transferrin receptors, the nanocomposites could be used selectively to recognize Hela cells in comparison with nonconjugated ones. These results indicate that the newly designed magnetic nanocomposites with PGMA as functional polymer could serve as a novel versatile platform to conjugate with various molecules for construction of diverse multifunctional magnetic nanocomposites to meet different requirements and potential uses in nanomedicine and biological chemistry. |
| 语种 | 英语 |
| WOS记录号 | WOS:000310066700025 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47331]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Ying,Zhao, Lingzhi,Qi, Li,et al. Reactive Polymer as a Versatile Toolbox for Construction of Multifunctional Superparamagnetic Nanocomposites[J]. CHEMISTRY-A EUROPEAN JOURNAL,2012,18(43):13755-13761. |
| APA | Shen, Ying,Zhao, Lingzhi,Qi, Li,Qiao, Juan,Mao, Lanqun,&Chen, Yi.(2012).Reactive Polymer as a Versatile Toolbox for Construction of Multifunctional Superparamagnetic Nanocomposites.CHEMISTRY-A EUROPEAN JOURNAL,18(43),13755-13761. |
| MLA | Shen, Ying,et al."Reactive Polymer as a Versatile Toolbox for Construction of Multifunctional Superparamagnetic Nanocomposites".CHEMISTRY-A EUROPEAN JOURNAL 18.43(2012):13755-13761. |
入库方式： OAI收割
来源：化学研究所
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