Synthesis of PEGylated fullerene-5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil
文献类型：期刊论文
| 作者 | Dou, Zengpei; Xu, Yingying; Sun, Hongfang; Liu, Yuanfang |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:15页码:4624-4630 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c2nr30380a |
| 英文摘要 | Many drugs have been delivered by different types of nanoscale vehicles to enhance their therapeutic efficacy. 5-Fluorouracil (5FU) is a widely used antitumor drug, however its bioavailability still needs to be improved. Herein we synthesized a polyethylene glycol monomethylether-C-60-5FU conjugate (mPEG-C-60-5FU) and evaluated its antitumor efficacy in vitro. The results show that the inhibition abilities of mPEG-C-60-5FU to the human breast cancer cell line MCF-7 and the human gastric carcinoma cell line BGC-823 are significantly higher than that of 5FU. The conjugate has good stability in murine serum for at least 24 h. Moreover, the PEGylated fullerene (mPEG-C-60) vehicle is non-toxic to MCF-7 cells. These results demonstrate that mPEG-C-60 is an efficient vehicle for the delivery of 5FU. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306324000041 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47337]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Sun, Hongfang |
| 作者单位 | Peking Univ, Beijing Natl Lab Mol Sci, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dou, Zengpei,Xu, Yingying,Sun, Hongfang,et al. Synthesis of PEGylated fullerene-5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil[J]. NANOSCALE,2012,4(15):4624-4630. |
| APA | Dou, Zengpei,Xu, Yingying,Sun, Hongfang,&Liu, Yuanfang.(2012).Synthesis of PEGylated fullerene-5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil.NANOSCALE,4(15),4624-4630. |
| MLA | Dou, Zengpei,et al."Synthesis of PEGylated fullerene-5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil".NANOSCALE 4.15(2012):4624-4630. |
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来源：化学研究所
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