Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer
文献类型：期刊论文
| 作者 | Wu, Suhong2,3; Kuang, Huihui2,3; Meng, Fanbo1; Wu, Yanjuan2,3; Li, Xiaoyuan2; Jing, Xiabin2; Huang, Yubin2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:30页码:15348-15356 |
| ISSN号 | 0959-9428 |
| DOI | 10.1039/c2jm32081a |
| 英文摘要 | Efficient delivery of anti-cancer drugs into tumor cells for enhancing the intracellular drug concentration is a major challenge for cancer therapy due to the instability of drug-loading vehicle. In this report, we developed a simple method to stabilize the nanostructure of micelles only by bubbling air to crosslink the outer layer of the micelle core. Dopamine was conjugated to a biodegradable triblock copolymer monomethoxy poly(ethylene glycol)-b-poly(2-methyl-2-carboxyl-propylene carbonate)-b-poly(L-lactide) (mPEG-b-PMCC-b-PLA) to obtain dopamine grafted copolymer mPEG-b-P(MCC-g-dopamine)-b-PLA. After self-assembly, the core cross-linked micelles were then prepared by the oxidative self-polymerization of dopamine in the middle hydrophobic phase of the micelles. The cross-linked micelles had smaller sizes and narrower particle size distributions than their uncross-linked precursors. The improved stability was confirmed by critical micelle concentration (CMC) experiments and H-1 NMR spectra. The kinetics and processes of oxidative cross-linking of micelles under air flux were monitored by UV-Vis spectroscopy and transmission electron microscopy (TEM). These core cross-linked micelles were able to load doxorubicin (DOX) with superior loading capacity of up to 19.5% (w/w, drug/micelle) with high drug loading efficiency (97.5%). Compared with the uncross-linked ones, drug release efficacy from the cross-linked micelles extremely decreased at pH 7.4. However, a properly sustained release occurred at pH 5.0, which is very favorable for drug delivery in tumor cells. The DOX-loaded micelles had similar cytotoxicity as the free drug and could be effectively internalized into MDA-MB-231 cells. This controllable and convenient approach for preparing core cross-linked micelles will have a pragmatic future in stabilizing the architecture of nanocarriers for drug delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306215900075 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47407]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Meng, Fanbo |
| 作者单位 | 1.Jilin Univ, China Japan Union Hosp, Dept Cardiol, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Suhong,Kuang, Huihui,Meng, Fanbo,et al. Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(30):15348-15356. |
| APA | Wu, Suhong.,Kuang, Huihui.,Meng, Fanbo.,Wu, Yanjuan.,Li, Xiaoyuan.,...&Huang, Yubin.(2012).Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer.JOURNAL OF MATERIALS CHEMISTRY,22(30),15348-15356. |
| MLA | Wu, Suhong,et al."Facile preparation of core cross-linked micelles from catechol-containing amphiphilic triblock copolymer".JOURNAL OF MATERIALS CHEMISTRY 22.30(2012):15348-15356. |
入库方式： OAI收割
来源：化学研究所
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