Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth
文献类型：期刊论文
| 作者 | Cui, Wenjuan; Li, Jinru; Zhang, Yakun; Rong, Huilin; Lu, Wensheng; Jiang, Long |
| 刊名 | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
 |
| 出版日期 | 2012 |
| 卷号 | 8期号:1页码:46-53 |
| 关键词 | Nanoparticles Hela Cell Escherichia Coli Cytotoxicity Inkjet Printing |
| ISSN号 | 1549-9634 |
| DOI | 10.1016/j.nano.2011.05.005 |
| 英文摘要 | The effect of gold nanoparticles (Au NPs) on cells remains open for investigation. Here we show that small Au NPs can be endocytosed by cells and form aggregates inside the cell, resulting in cytotoxicity. When the aggregates become too large to enter the cell and instead adhere onto the cell surface, however, the growth rate of HeLa cells increases. Printed patterns of Au NPs fabricated through inkjet printing technology were used to study the effects of Au NP aggregation on human cervical carcinoma (HeLa) cell activity. The growth of the HeLa cells was inhibited on the polymer-coated Au NPs but increased on the silicon substrate. On the uncoated Au NP surface, however, the HeLa cell growth rate was higher than that on the silicon substrate. Experiments with Escherichia coli cells showed a similar effect of the Au NPs. This phenomenon provides a new perspective for research on toxicity in nanoparticle biology. |
| 语种 | 英语 |
| WOS记录号 | WOS:000299010500007 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47515]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jiang, Long |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Colloids & Surfaces, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Wenjuan,Li, Jinru,Zhang, Yakun,et al. Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2012,8(1):46-53. |
| APA | Cui, Wenjuan,Li, Jinru,Zhang, Yakun,Rong, Huilin,Lu, Wensheng,&Jiang, Long.(2012).Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,8(1),46-53. |
| MLA | Cui, Wenjuan,et al."Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 8.1(2012):46-53. |
入库方式： OAI收割
来源：化学研究所
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