Construction and Evaluation of Hemoglobin-Based Capsules as Blood Substitutes
文献类型：期刊论文
| 作者 | Jia, Yi1; Cui, Yue1; Fei, Jinbo1; Du, Mingchun1; Dai, Luru2; Li, Junbai1,2; Yang, Yang2 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2012-04-10 |
| 卷号 | 22期号:7页码:1446-1453 |
| 关键词 | Capsules Hemoglobin Biocompatibility Hemocompatibility Blood Substitutes |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201102737 |
| 英文摘要 | Hemoglobin-based capsules for use as blood substitutes are successfully fabricated by covalent layer-by-layer assembly. Dialdehyde heparin (DHP) is used both as one of the wall components and a cross-linker without employing other extraneous or toxic crosslinking agents. The biocompatibility of (Hb/DHP)6 microcapsules is evaluated through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and cell experiments. The hemocompatibility of (Hb/DHP)6 microcapsules is characterized in terms of prothrombin time, thrombin time, activated partial thromboplastin time, and hemolysis rate. The oxygen-carrying capacity of the microcapsules is demonstrated by converting the deoxy-Hb state of the microcapsules into the oxy-Hb state. All these results demonstrate that the hemoglobin-based microcapsules exhibit oxygen-carrying capacity as well as biocompatibility and hemocompatility, indicating that the as-prepared capsules have great potential to function as blood substitutes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000302346400013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47523]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jia, Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid & Interface Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Yi,Cui, Yue,Fei, Jinbo,et al. Construction and Evaluation of Hemoglobin-Based Capsules as Blood Substitutes[J]. ADVANCED FUNCTIONAL MATERIALS,2012,22(7):1446-1453. |
| APA | Jia, Yi.,Cui, Yue.,Fei, Jinbo.,Du, Mingchun.,Dai, Luru.,...&Yang, Yang.(2012).Construction and Evaluation of Hemoglobin-Based Capsules as Blood Substitutes.ADVANCED FUNCTIONAL MATERIALS,22(7),1446-1453. |
| MLA | Jia, Yi,et al."Construction and Evaluation of Hemoglobin-Based Capsules as Blood Substitutes".ADVANCED FUNCTIONAL MATERIALS 22.7(2012):1446-1453. |
入库方式： OAI收割
来源：化学研究所
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