PEGylated Click Polypeptides Synthesized by Copper-Free Microwave-Assisted Thermal Click Polymerization for Selective Endotoxin Removal from Protein Solutions
文献类型：期刊论文
| 作者 | Guo, Jinshan2; Meng, Fanbo1; Li, Xiaoyuan2; Wang, Mingzhe2; Wu, Yanjuan2; Jing, Xiabin2; Huang, Yubin2 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 12期号:4页码:533-546 |
| 关键词 | Biological Applications Of Polymers Endotoxin Removal Pegylation Step-growth Polymerization Thermal Click Chemistry |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201100394 |
| 英文摘要 | PEGylated click polypeptides (PEG-CPs) containing a-amino side groups as well as PEG segments are designed for selective endotoxin removal from protein solutions. The PEG-CPs are synthesized via copper-free thermal click copolymerization from aspartic (or glutamic) acid-based dialkyne and diazide monomers (containing free amino side groups) and alkyne-terminated mPEGs or dialkyne-terminated PEGs. Microwave-assisting technology is introduced into thermal click chemistry to improve the reaction efficiency. The monomers and polymers are fully characterized using NMR, XPS, and MALDI-TOF MS. After immobilizing the PEGylated click polypeptides onto polystyrene microspheres, the adsorbents exhibit good endotoxin removal selectivity from BSA solutions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000302622200014 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47651]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Meng, Fanbo |
| 作者单位 | 1.Jilin Univ, Dept Cardiol, China Japan Union Hosp, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jinshan,Meng, Fanbo,Li, Xiaoyuan,et al. PEGylated Click Polypeptides Synthesized by Copper-Free Microwave-Assisted Thermal Click Polymerization for Selective Endotoxin Removal from Protein Solutions[J]. MACROMOLECULAR BIOSCIENCE,2012,12(4):533-546. |
| APA | Guo, Jinshan.,Meng, Fanbo.,Li, Xiaoyuan.,Wang, Mingzhe.,Wu, Yanjuan.,...&Huang, Yubin.(2012).PEGylated Click Polypeptides Synthesized by Copper-Free Microwave-Assisted Thermal Click Polymerization for Selective Endotoxin Removal from Protein Solutions.MACROMOLECULAR BIOSCIENCE,12(4),533-546. |
| MLA | Guo, Jinshan,et al."PEGylated Click Polypeptides Synthesized by Copper-Free Microwave-Assisted Thermal Click Polymerization for Selective Endotoxin Removal from Protein Solutions".MACROMOLECULAR BIOSCIENCE 12.4(2012):533-546. |
入库方式： OAI收割
来源：化学研究所
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