Synthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated imines
文献类型：期刊论文
| 作者 | Tong, Shuo1; Yang, Xu2; Wang, De-Xian1; Zhao, Liang2; Zhu, Jieping2,3; Wang, Mei-Xiang1,2 |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2012-08-12 |
| 卷号 | 68期号:32页码:6492-6497 |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2012.05.108 |
| 英文摘要 | The reactivity of stable tertiary enamides in nucleophilic addition reaction with various in-situ generated imines was explored. Under very mild conditions, formyl-bearing tertiary enamides reacted with both aromatic and aliphatic amines to form imine intermediates. In the absence or presence of p-toluenesulfonic acid as a catalyst, intramolecular nucleophilic addition of enamide to imine functionality proceeded effectively to produce diverse 4-amino-1,2,3,4-tetrahydropyridine derivatives in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306267800012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47779]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Mei-Xiang |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Chem, MOST Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China 3.EPFL SB ISIC LSPN, Inst Chem Sci & Engn, Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland |
| 推荐引用方式 GB/T 7714 | Tong, Shuo,Yang, Xu,Wang, De-Xian,et al. Synthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated imines[J]. TETRAHEDRON,2012,68(32):6492-6497. |
| APA | Tong, Shuo,Yang, Xu,Wang, De-Xian,Zhao, Liang,Zhu, Jieping,&Wang, Mei-Xiang.(2012).Synthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated imines.TETRAHEDRON,68(32),6492-6497. |
| MLA | Tong, Shuo,et al."Synthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated imines".TETRAHEDRON 68.32(2012):6492-6497. |
入库方式： OAI收割
来源：化学研究所
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