Three-dimensional domain swapping in the protein structure space
文献类型：期刊论文
| 作者 | Huang, Yongqi1,2,3,4; Cao, Huaiqing2,3,4; Liu, Zhirong2,3 |
| 刊名 | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
 |
| 出版日期 | 2012-06-01 |
| 卷号 | 80期号:6页码:1610-1619 |
| 关键词 | Domain Swapping Dataset Scop Protein-protein Interaction Hinge Loop Interface |
| ISSN号 | 0887-3585 |
| DOI | 10.1002/prot.24055 |
| 英文摘要 | Since the proposal of three-dimensional (3D) domain swapping, many 3D domain-swapped structures have been reported. However, when compared with the vast protein structure space, it is still unclear whether 3D domain swapping is a general mechanism for protein assembly. Here, we investigated this possibility by constructing a dataset consisting of more than 500 domain-swapped structures. The domain-swapped structures were mapped into the protein structure space. We found that about 10% of protein folds and 5% of protein families contain domain-swapped structures. When comparing the domain-swapped structures in a family/superfamily, we found that proteins within a family/superfamily can swap in different ways. Interface analysis revealed that the hinge loops contributed more than half of the open interface in 70% of bona fide domain-swapped dimers, indicating that the hinge loops play an important role in stabilizing the domain-swapped conformations. Our study supports the suggestion that domain swapping is a general property of all proteins and will facilitate further understanding the mechanism of 3D domain swapping. Proteins 2012. (c) 2012 Wiley Periodicals, Inc. |
| 语种 | 英语 |
| WOS记录号 | WOS:000303759000008 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47823]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Zhirong |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Univ, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 3.Peking Univ, BNLMS, Beijing 100871, Peoples R China 4.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yongqi,Cao, Huaiqing,Liu, Zhirong. Three-dimensional domain swapping in the protein structure space[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2012,80(6):1610-1619. |
| APA | Huang, Yongqi,Cao, Huaiqing,&Liu, Zhirong.(2012).Three-dimensional domain swapping in the protein structure space.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,80(6),1610-1619. |
| MLA | Huang, Yongqi,et al."Three-dimensional domain swapping in the protein structure space".PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 80.6(2012):1610-1619. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。