Biological Characterization of Folate-Decorated Biodegradable Polymer-Platinum(II) Complex Micelles
文献类型：期刊论文
| 作者 | Wang, Rui1,2; Hu, Xiuli1; Wu, Sai3; Xiao, Haihua1,2; Cai, Haidong4; Xie, Zhigang1; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | MOLECULAR PHARMACEUTICS
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 9期号:11页码:3200-3208 |
| 关键词 | Folic Acid Targeting Biodegradable Multifunctional Micelles Polymer-platinum Complex Oxaliplatin |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/mp3002914 |
| 英文摘要 | A biodegradable and amphiphilic copolymer, poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (mPEG-b-P(LA-co-MCC)), which contains pendant carboxyl groups, was chosen as a drug carrier for the active anticancer part (diaminocyclohexane platinum, DACH-Pt) of oxaliplatin to form mPEG-b-P(LA-co-MCC/Pt) complex. A folic acid-conjugated copolymer, folic acid poly(ethylene glycol)-block-poly(L-lactide) (FA PEG-PLA), with similar chemical structure was chosen for targeting. Multifunctional micelles were successfully prepared by a coassembling method. In vitro evaluation was performed by using SKOV-3 and MCF-7 cancer cells. In vivo blood clearance of platinum was studied, and the results show that micelles exhibit longer blood circulation after iv injection. Pt biodistribution was studied by measuring its levels in plasma, organs, and tumors, especially in tumor cell DNA, by atomic absorption and inductively coupled plasma mass spectrometry. Antitumor activity was assessed in mice bearing H22 liver cancers, and the results showed that the micelles with FA moieties exhibited greater antitumor efficacy than those without FA or oxaliplatin. Therefore, these novel multifunctional platinum micelles have great potential in future clinical application. |
| 语种 | 英语 |
| WOS记录号 | WOS:000313769200022 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47875]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Hu, Xiuli |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Jilin Univ, Dept Mat Sci & Engn, Changchun 130022, Peoples R China 4.Changchun Univ Sci & Technol, Dept Chem & Environm Engn, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Rui,Hu, Xiuli,Wu, Sai,et al. Biological Characterization of Folate-Decorated Biodegradable Polymer-Platinum(II) Complex Micelles[J]. MOLECULAR PHARMACEUTICS,2012,9(11):3200-3208. |
| APA | Wang, Rui.,Hu, Xiuli.,Wu, Sai.,Xiao, Haihua.,Cai, Haidong.,...&Jing, Xiabin.(2012).Biological Characterization of Folate-Decorated Biodegradable Polymer-Platinum(II) Complex Micelles.MOLECULAR PHARMACEUTICS,9(11),3200-3208. |
| MLA | Wang, Rui,et al."Biological Characterization of Folate-Decorated Biodegradable Polymer-Platinum(II) Complex Micelles".MOLECULAR PHARMACEUTICS 9.11(2012):3200-3208. |
入库方式： OAI收割
来源：化学研究所
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