Theoretical Studies of the Asymmetric Binary-Acid-Catalyzed tert-Aminocyclization Reaction: Origins of the C-sp3-H Activation and Stereoselectivity
文献类型：期刊论文
| 作者 | Zhang, Long; Chen, Liujuan; Lv, Jian; Cheng, Jin-Pei; Luo, Sanzhong |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 7期号:11页码:2569-2576 |
| 关键词 | c?c?C?c?h Activation Density Functional Calculations Lewis Acids Phosphoric Acid Tert-aminocyclization |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201200674 |
| 英文摘要 | A mechanistic study of the tert-aminocyclization reaction was performed by using DFT calculations and labeling experiments. The results showed that the reaction proceeded through a rate-limiting-, stereospecific-, and suprafacial 1,5-H-transfer pathway, followed by a barrier-less C?C bond formation. The mode of stereocontrol for facial selection could be ruled out owing to the high activation energy of C?N bond rotation. The intrinsic feature of this Lewis acid activation was found to be the activation of the LUMO, as well as an intermediate-stabilization effect. The catalytically active species was believed to be a 1:1 complex of phosphoric acid and MgCl2, which was stabilized by a H...Cl hydrogen bond. The chiral catalytic complex selectively recognizes and activates one of the two helical conformations of substrate A, required for 1,5-suprafacial H-transfer, which dictates the stereoselectivity of the forming products. |
| 语种 | 英语 |
| WOS记录号 | WOS:000309717300017 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47877]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Luo, Sanzhong |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Mol Recognit & Funct Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Long,Chen, Liujuan,Lv, Jian,et al. Theoretical Studies of the Asymmetric Binary-Acid-Catalyzed tert-Aminocyclization Reaction: Origins of the C-sp3-H Activation and Stereoselectivity[J]. CHEMISTRY-AN ASIAN JOURNAL,2012,7(11):2569-2576. |
| APA | Zhang, Long,Chen, Liujuan,Lv, Jian,Cheng, Jin-Pei,&Luo, Sanzhong.(2012).Theoretical Studies of the Asymmetric Binary-Acid-Catalyzed tert-Aminocyclization Reaction: Origins of the C-sp3-H Activation and Stereoselectivity.CHEMISTRY-AN ASIAN JOURNAL,7(11),2569-2576. |
| MLA | Zhang, Long,et al."Theoretical Studies of the Asymmetric Binary-Acid-Catalyzed tert-Aminocyclization Reaction: Origins of the C-sp3-H Activation and Stereoselectivity".CHEMISTRY-AN ASIAN JOURNAL 7.11(2012):2569-2576. |
入库方式： OAI收割
来源：化学研究所
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