Effect of size and dose on the biodistribution of graphene oxide in mice
文献类型：期刊论文
| 作者 | Liu, Jia-Hui1,2; Yang, Sheng-Tao1,2; Wang, Haifang1; Chang, Yanli1; Cao, Aoneng1; Liu, Yuanfang2 |
| 刊名 | NANOMEDICINE
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 7期号:12页码:1801-1812 |
| 关键词 | Biodistribution Dose Graphene Oxide Isotope Labeling Size Effect |
| ISSN号 | 1743-5889 |
| DOI | 10.2217/NNM.12.60 |
| 英文摘要 | Aim: Graphene oxide (GO) has promising applications in bioimaging, diagnostics and therapeutics. This work studied the effects of size and injection dose on the biodistribution of GO to accelerate the development of a GO-based drug. Methods: GO samples were intravenously injected into mice. The content of GO in organs/tissues at different time points was measured using an I-125-labeling technique. GO in the liver and lungs was further confirmed by both Raman spectroscopic and TEM observations. The dispersion state of GO in serum was evaluated by flow cytometry. Results: Regardless of size, GO was cleared from the blood quickly and accumulated mainly in the liver and lungs. The uptake of GO in lungs increased with increasing injection dose and size. The dispersion state (i.e., size of the GO-protein complex in blood) dominated the biodistribution. Conclusion: The size and dose of GO affected its fate in vivo. For medical applications, small-sized GO with suitable funtionalization is recommended. Original submitted 30 November 2011; Revised submitted 23 March 2012; Published online on 26 July 2012 |
| 语种 | 英语 |
| WOS记录号 | WOS:000312419900010 |
| 出版者 | FUTURE MEDICINE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47931]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Haifang |
| 作者单位 | 1.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jia-Hui,Yang, Sheng-Tao,Wang, Haifang,et al. Effect of size and dose on the biodistribution of graphene oxide in mice[J]. NANOMEDICINE,2012,7(12):1801-1812. |
| APA | Liu, Jia-Hui,Yang, Sheng-Tao,Wang, Haifang,Chang, Yanli,Cao, Aoneng,&Liu, Yuanfang.(2012).Effect of size and dose on the biodistribution of graphene oxide in mice.NANOMEDICINE,7(12),1801-1812. |
| MLA | Liu, Jia-Hui,et al."Effect of size and dose on the biodistribution of graphene oxide in mice".NANOMEDICINE 7.12(2012):1801-1812. |
入库方式： OAI收割
来源：化学研究所
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