Fabrication, Crosslinking and in vitro Biocompatibility of a Novel Degradable Nano-structure Urethral Tubular Scaffold
文献类型：期刊论文
| 作者 | Wang Xiao-qing1; Chen Qi-hui1; Hou Yu-chuan1; Lu Zhi-hua1; Ru Jing-hai1; Zhang Hai-feng1; Hao Yuan-yuan1; Zhang Long1; Gao Zhan-tuan2; Wang Chun-xi1 |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 28期号:5页码:912-915 |
| 关键词 | Poly(Lactic-co-glycolic Acid) Urethral Scaffold Degradable Electrospin Crosslinking |
| ISSN号 | 1005-9040 |
| 英文摘要 | A degradable poly(lactic-co-glycolic acid, LA:GA=80:20)(PLGA) urethral tubular scaffold was fabricated by electrospinning. In order to enhance the mechanical properties, the scaffold was crosslinked with glutaraldehyde. The structure and properties of the crosslinked scaffolds were investigated by the mechanical property testing, scanning electron microscopy(SEM), degradability test in vitro and 3-(4,5)-dimethylthiahiazo(-z-yl)-3,5-diphenytetrazo-liumromide(MTT). The results show that the scaffold has the nano-structure. The pore size and the porosity are suitable for cell seeding, growth and extracellular matrix production. Although influenced by the crosslinking slightly, the pore size and the porosity could still support cell proliferation and tissuse formation. The mechanical properties are remarkably increased by the crosslinking of glutaraldehyde, and it could meet the demands of a urethral stent. The scaffold could completely collapse within 70 d. The results of the biocompatibility test show that the PLGA scaffold had no cytotoxicity. |
| 语种 | 英语 |
| WOS记录号 | WOS:000312475400035 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/47963]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang Chun-xi |
| 作者单位 | 1.Jilin Univ, Dept Urol, Hosp 1, Changchun 130021, Peoples R China 2.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Xiao-qing,Chen Qi-hui,Hou Yu-chuan,et al. Fabrication, Crosslinking and in vitro Biocompatibility of a Novel Degradable Nano-structure Urethral Tubular Scaffold[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2012,28(5):912-915. |
| APA | Wang Xiao-qing.,Chen Qi-hui.,Hou Yu-chuan.,Lu Zhi-hua.,Ru Jing-hai.,...&Wang Chun-xi.(2012).Fabrication, Crosslinking and in vitro Biocompatibility of a Novel Degradable Nano-structure Urethral Tubular Scaffold.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,28(5),912-915. |
| MLA | Wang Xiao-qing,et al."Fabrication, Crosslinking and in vitro Biocompatibility of a Novel Degradable Nano-structure Urethral Tubular Scaffold".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 28.5(2012):912-915. |
入库方式： OAI收割
来源：化学研究所
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