The Interaction of Telomeric DNA and C-myc22 G-Quadruplex with 11 Natural Alkaloids
文献类型：期刊论文
| 作者 | Ji, Xiaohui1; Sun, Hongxia2; Zhou, Huaxi3; Xiang, Junfeng2; Tang, Yalin2; Zhao, Changqi1 |
| 刊名 | NUCLEIC ACID THERAPEUTICS
 |
| 出版日期 | 2012-04-01 |
| 卷号 | 22期号:2页码:127-136 |
| ISSN号 | 2159-3337 |
| DOI | 10.1089/nat.2012.0342 |
| 英文摘要 | Telomeric DNA and C-myc22 are DNA G-quadruplex (G4)-forming sequences associated with tumorigenesis. Ligands that can facilitate the formation and increase the stabilization of G4 can halt tumor cell proliferation and have been regarded as potential anti-cancer drugs. In the present study, we have investigated the interaction of 11 natural alkaloids with G4 formed by telomeric DNA and C-myc22 sequences. Our results indicated that sanguinarine (San), palmatine (Pal), and berberine (Beb) of the first series (S1) can induce the formation of G4 as well as increase the stabilization ability. Daurisoline (S2-1), O-methyldauricine (S2-2), O-diacetyldaurisoline (S2-3), daurinoline (S2-4), dauricinoline (S2-5), N,N'-dimethyldauricine iodide (S2-6), and N,N'-dimethyldaurisoline iodide (S2-7) of the second series (S2) showed similar stabilization ability. We found that unsaturated ring C, N+ positively charged centers, and conjugated aromatic rings are key factors to increase the stabilization ability of S1, and we gave some advice on structure modification to S2 through structure-activity study. Besides, we found San and Pal to be cell cycle blocker in G(1). San was speculated to bind to G4 through intercalation or end stacking. |
| 语种 | 英语 |
| WOS记录号 | WOS:000302770600009 |
| 出版者 | MARY ANN LIEBERT INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48001]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Changqi |
| 作者单位 | 1.Beijing Normal Univ, Key Lab Cell Proliferat & Regulat Biol, Beijing Key Lab Gene Engn Drugs & Biol Technol, Minist Educ,Coll Life Sci, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Inst Chem, Beijing 100080, Peoples R China 3.Beijing Normal Univ, Dept Syst Sci, Sch Management, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Xiaohui,Sun, Hongxia,Zhou, Huaxi,et al. The Interaction of Telomeric DNA and C-myc22 G-Quadruplex with 11 Natural Alkaloids[J]. NUCLEIC ACID THERAPEUTICS,2012,22(2):127-136. |
| APA | Ji, Xiaohui,Sun, Hongxia,Zhou, Huaxi,Xiang, Junfeng,Tang, Yalin,&Zhao, Changqi.(2012).The Interaction of Telomeric DNA and C-myc22 G-Quadruplex with 11 Natural Alkaloids.NUCLEIC ACID THERAPEUTICS,22(2),127-136. |
| MLA | Ji, Xiaohui,et al."The Interaction of Telomeric DNA and C-myc22 G-Quadruplex with 11 Natural Alkaloids".NUCLEIC ACID THERAPEUTICS 22.2(2012):127-136. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。