Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins
文献类型：期刊论文
| 作者 | Zhao, Mei-Xin1,2,3; Chen, Ming-Xiao1,2; Tang, Wen-Hao1,2; Wei, Deng-Ke1,2; Dai, Tong-Lei1,2; Shi, Min1,2,4 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2012-07-01 |
| 期号 | 19页码:3598-3606 |
| 关键词 | Organocatalysis Amination Alkaloids Allylic Compounds Isatins Carbonates |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201200376 |
| 英文摘要 | An efficient enantioselective allylic amination of MoritaBaylisHillman (MBH) carbonates derived from methyl acrylate and aromatic aldehydes with isatins has been realized in the presence of commercially available cinchona alkaloids. The allylic amination products were obtained in moderate-to-good yields (4674?%) with moderate-to-good enantioselectivities (up to 89?% ee) under mild conditions. The synthetic utility of the amination products has been well demonstrated by the facile synthesis of methyl (3R,4R)-10-oxo-4-phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indole-3-carboxylate. |
| 语种 | 英语 |
| WOS记录号 | WOS:000305510400008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48003]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Mei-Xin |
| 作者单位 | 1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Mei-Xin,Chen, Ming-Xiao,Tang, Wen-Hao,et al. Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(19):3598-3606. |
| APA | Zhao, Mei-Xin,Chen, Ming-Xiao,Tang, Wen-Hao,Wei, Deng-Ke,Dai, Tong-Lei,&Shi, Min.(2012).Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(19),3598-3606. |
| MLA | Zhao, Mei-Xin,et al."Cinchona Alkaloid Catalyzed Regio- and Enantioselective Allylic Amination of Morita-Baylis-Hillman Carbonates with Isatins".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .19(2012):3598-3606. |
入库方式： OAI收割
来源：化学研究所
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