A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior
文献类型：期刊论文
| 作者 | Li, Bin2,3; Chen, Gao2,3; Meng, Fanbo1; Li, Taihang2,3; Yue, Jun2,3; Jing, Xiabin3; Huang, Yubin3 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 3期号:9页码:2421-2429 |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c2py20253k |
| 英文摘要 | New amphiphilic graft copolymers with hydrophilic poly(ethylene oxide-co-allyl glycidyl ether) (PEAG) as the backbone and hydrophobic poly(epsilon-caprolactone) (PCL) as the side chains (PEAG-g-PCL) were designed and synthesized. For this purpose, the combined techniques of anionic copolymerization, radical mediated thiol-ene reaction and ring-opening polymerization were employed. The properties of the graft copolymer were characterized by H-1 NMR, C-13 NMR, GPC and MALDI-TOF-MS. The self-assembly of the copolymers in aqueous solution was examined by fluorescence spectroscopy, DLS and TEM. The results showed that with a relatively low critical aggregation concentration (CAC), the graft copolymers could form different morphologies including vesicles (polymersomes). The formed polymersomes had the capacity to encapsulate protein molecules (like hemoglobin, Hb) through a modified lyophilization-rehydration method as analyzed via TEM and SDS-PAGE. Furthermore the gas-binding capacity of the encapsulated Hb was assayed via UV-vis spectroscopy. The characteristic absorption peak of the encapsulated Hb in different gas-binding states (CO, O-2, N-2) showed no significant change by comparison with that of free Hb. These Hb encapsulated PEAG-g-PCL polymersomes could have the potential to be applied as an artificial oxygen carrier for transfusion. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306967600013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48017]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Meng, Fanbo |
| 作者单位 | 1.Jilin Univ, China Japan Union Hosp, Dept Cardiol, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bin,Chen, Gao,Meng, Fanbo,et al. A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior[J]. POLYMER CHEMISTRY,2012,3(9):2421-2429. |
| APA | Li, Bin.,Chen, Gao.,Meng, Fanbo.,Li, Taihang.,Yue, Jun.,...&Huang, Yubin.(2012).A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior.POLYMER CHEMISTRY,3(9),2421-2429. |
| MLA | Li, Bin,et al."A novel amphiphilic copolymer poly(ethylene oxide-co-allyl glycidyl ether)-graft-poly(epsilon-caprolactone): synthesis, self-assembly, and protein encapsulation behavior".POLYMER CHEMISTRY 3.9(2012):2421-2429. |
入库方式： OAI收割
来源：化学研究所
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