Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier
文献类型：期刊论文
| 作者 | Yue, Jun1,2; Liu, Shi1; Wang, Rui1,2; Hu, Xiuli1; Xie, Zhigang1; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 12期号:9页码:1209-1219 |
| 关键词 | Biodegradable Biodistribution Blood-brain Barrier Micelles Ox26 |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201200037 |
| 英文摘要 | Multifunctional hybrid micelles are prepared from amphiphilic mal-PEG-b-PLA and mPEG-b-P(LA-co-DHC/RhB) block copolymers. A specific anti-transferrin receptor antibody, OX26, is linked onto the surface of the micelles. ELISA indicates that the conjugated antibody preserves its activity. OX26 conjugation can increase the uptake efficiency of micelles by target cell lines (C6). Pharmacokinetics and in vivo biodistribution experiments are carried out to investigate the ability of OX26-conjugated micelles (immunomicelles) to cross the bloodbrain barrier. The data show that the brain uptake of OX26-conjugated micelles is much more than that of OX26-free ones. Therefore, OX26-conjugated micelles will be promising drug carriers to cross the blood-brain barrier. |
| 语种 | 英语 |
| WOS记录号 | WOS:000308393100008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48169]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Jun,Liu, Shi,Wang, Rui,et al. Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier[J]. MACROMOLECULAR BIOSCIENCE,2012,12(9):1209-1219. |
| APA | Yue, Jun.,Liu, Shi.,Wang, Rui.,Hu, Xiuli.,Xie, Zhigang.,...&Jing, Xiabin.(2012).Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier.MACROMOLECULAR BIOSCIENCE,12(9),1209-1219. |
| MLA | Yue, Jun,et al."Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood-Brain Barrier".MACROMOLECULAR BIOSCIENCE 12.9(2012):1209-1219. |
入库方式： OAI收割
来源：化学研究所
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