Screening alpha-glucosidase inhibitors from mulberry extracts via DOSY and relaxation-edited NNR
文献类型：期刊论文
| 作者 | Shang, Qian; Xiang, Jun-Feng; Tang, Ya-Lin |
| 刊名 | TALANTA
 |
| 出版日期 | 2012-08-15 |
| 卷号 | 97页码:362-367 |
| ISSN号 | 0039-9140 |
| 关键词 | Screening Alpha-glucosidase Inhibitor Dosy Relaxation-edited Nmr |
| DOI | 10.1016/j.talanta.2012.04.046 |
| 英文摘要 | Inhibition of the alpha-glucosidase activity is a therapeutic approach for diabetes. In this study, an effective strategy for screening alpha-glucosidase inhibitors based on Nuclear magnetic resonance (NMR) techniques was developed to screen and identify alpha-glucosidase inhibitors from Mulberry leaf extract. As a result, deoxynojirimycin, as a potential alpha-glucosidase inhibitor, was found. The study suggested that our strategy was a powerful tool for screening and identification of alpha-glucosidase inhibitors in complex samples. Furthermore the interaction between alpha-glucosidase and its inhibitor was studied by NMR. 2012 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000308268800054 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48209]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tang, Ya-Lin |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, BNLMS,Ctr Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shang, Qian,Xiang, Jun-Feng,Tang, Ya-Lin. Screening alpha-glucosidase inhibitors from mulberry extracts via DOSY and relaxation-edited NNR[J]. TALANTA,2012,97:362-367. |
| APA | Shang, Qian,Xiang, Jun-Feng,&Tang, Ya-Lin.(2012).Screening alpha-glucosidase inhibitors from mulberry extracts via DOSY and relaxation-edited NNR.TALANTA,97,362-367. |
| MLA | Shang, Qian,et al."Screening alpha-glucosidase inhibitors from mulberry extracts via DOSY and relaxation-edited NNR".TALANTA 97(2012):362-367. |
入库方式： OAI收割
来源：化学研究所
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