A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance
文献类型：期刊论文
| 作者 | Xiao, Haihua1,2; Song, Haiqin3; Yang, Qiang4; Cai, Haidong5; Qi, Ruogu1,2; Yan, Lesan1,2; Liu, Shi1; Zheng, Yonghui1; Huang, Yubin1; Liu, Tongjun3 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 33期号:27页码:6507-6519 |
| 关键词 | Platinum Drug Paclitaxel Combination Therapy Drug Delivery Micelles |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2012.05.049 |
| 英文摘要 | A strategy of preparing composite micelles containing both cisplatin(IV) prodrug and paclitaxel was developed, i.e., synthesizing a cisplatin(IV) conjugate and a paclitaxel conjugate starting with the same biodegradable and amphiphilic block copolymer, and co-assembling the two conjugates. The composite micelles could release effective anticancer drug cisplatin(II) upon cellular reduction and PTX via acid hydrolysis once they came into the cancerous cells. Moreover, the composite micelles displayed synergistic effect in vitro and the combination therapy in micellar dosage-form led to reduced systematic toxicity and enhanced antitumor efficacy in vivo. (c) 2012 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000307148200021 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48271]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Jilin Univ, China Japan Union Hosp, Dept Colorectal & Anal Surg, Changchun 130033, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Obstet & Gynecol, Wuhan 430074, Peoples R China 5.Changchun Univ Sci & Technol, Dept Chem & Environm Engn, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Haihua,Song, Haiqin,Yang, Qiang,et al. A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance[J]. BIOMATERIALS,2012,33(27):6507-6519. |
| APA | Xiao, Haihua.,Song, Haiqin.,Yang, Qiang.,Cai, Haidong.,Qi, Ruogu.,...&Jing, Xiabin.(2012).A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance.BIOMATERIALS,33(27),6507-6519. |
| MLA | Xiao, Haihua,et al."A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance".BIOMATERIALS 33.27(2012):6507-6519. |
入库方式： OAI收割
来源：化学研究所
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