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An Anticoagulant Activity System Using Nanoengineered Autofluorescent Heparin Nanotubes

文献类型：期刊论文

作者Cui, Wei1; Cui, Yue1; Zhu, Pengli1; Zhao, Jie1; Su, Ying1; Yang, Yang2; Li, Junbai1
刊名CHEMISTRY-AN ASIAN JOURNAL
出版日期2012-01-02
卷号7期号:1页码:127-132
关键词Anticoagulant Activity Fluorescence Layer-by-layer Method Nanotubes Self-assembly
ISSN号1861-4728
DOI10.1002/asia.201100425
英文摘要Heparin (HEP) and periodate-oxidized heparin (O-HEP) nanotubes were prepared by combining the template method with a layer-by-layer (LbL) technique. The tubular structure was obtained and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and confocal laser scanning microscopy (CLSM). O-HEP is one of the HEP derivatives that contains anticoagulant activity and preserves its ability for other effects. Chitosan (CHI) and O-HEP have been used to fabricate nanotubes by covalent cross-linking Schiff base reactions. It is demonstrated that the obtained nanotubes have the significant feature of autofluorescence without the addition of any fluorescent dyes and they retain their anticoagulation activity. Compared with O-HEP/CHI nanotubes, HEP/CHI nanotubes show high anticoagulation activity and do not have autofluorescence. Furthermore, this method could be extended to other copolysaccharide derivatives for the preparation of autofluorescent nanomaterials.
语种英语
WOS记录号WOS:000298483600017
出版者WILEY-V C H VERLAG GMBH
源URL[http://ir.iccas.ac.cn/handle/121111/48315]  
专题中国科学院化学研究所
通讯作者Li, Junbai
作者单位1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Wei,Cui, Yue,Zhu, Pengli,et al. An Anticoagulant Activity System Using Nanoengineered Autofluorescent Heparin Nanotubes[J]. CHEMISTRY-AN ASIAN JOURNAL,2012,7(1):127-132.
APA Cui, Wei.,Cui, Yue.,Zhu, Pengli.,Zhao, Jie.,Su, Ying.,...&Li, Junbai.(2012).An Anticoagulant Activity System Using Nanoengineered Autofluorescent Heparin Nanotubes.CHEMISTRY-AN ASIAN JOURNAL,7(1),127-132.
MLA Cui, Wei,et al."An Anticoagulant Activity System Using Nanoengineered Autofluorescent Heparin Nanotubes".CHEMISTRY-AN ASIAN JOURNAL 7.1(2012):127-132.

入库方式： OAI收割

来源：化学研究所

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