Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering
文献类型：期刊论文
| 作者 | Zhou, Ying1,2; Xu, Ling1,2; Zhang, Xiangmei2; Zhao, Yinghui2; Wei, Shicheng2,3; Zhai, Maolin4 |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 32期号:4页码:994-1000 |
| 关键词 | Gelatin Carboxymethyl Chitosan Beta-tricalcium Phosphate Ultrasonic Treatment Radiation Crosslinking Bone Tissue Engineering |
| ISSN号 | 0928-4931 |
| DOI | 10.1016/j.msec.2012.02.029 |
| 英文摘要 | A series of biodegradable composite scaffolds was fabricated from an aqueous solution of gelatin, carboxymethyl chitosan (CM-chitosan) and beta-tricalcium phosphate (beta-TCP) by radiation-induced crosslinking at ambient temperature. Ultrasonic treatment on the polymer solutions significantly influenced the distribution of (beta-TCP particles. An ultrasonic time of 20 min, followed by 30 kGy irradiation induced a crosslinked scaffold with homogeneous distribution of beta-TCP particles, interconnected porous structure, sound swelling capacity and mechanical strength. Fourier Transform Infrared Spectroscopy and X-ray Diffraction analysis indicated that beta-TCP successfully incorporated with the network of gelatin and CM-chitosan. In vivo implantation of the scaffold into the mandible of beagle dog revealed that the scaffolds had excellent biocompatibility and the presence of beta-TCP can accelerate bone regeneration. The comprehensive results of this study paved way for the application of gelatin/CM-chitosan/beta-TCP composite scaffolds as candidate of bone tissue engineering material. (C) 2012 Elsevier By. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000303299300054 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48405]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, Ling |
| 作者单位 | 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 2.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 3.Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100081, Peoples R China 4.Peking Univ, Beijing Natl Lab Mol Sci, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Ying,Xu, Ling,Zhang, Xiangmei,et al. Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2012,32(4):994-1000. |
| APA | Zhou, Ying,Xu, Ling,Zhang, Xiangmei,Zhao, Yinghui,Wei, Shicheng,&Zhai, Maolin.(2012).Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,32(4),994-1000. |
| MLA | Zhou, Ying,et al."Radiation synthesis of gelatin/CM-chitosan/beta-tricalcium phosphate composite scaffold for bone tissue engineering".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 32.4(2012):994-1000. |
入库方式： OAI收割
来源：化学研究所
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