Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives
文献类型：期刊论文
| 作者 | Jin, Yue; Chen, Cheng; Meng, Lingchen; Chen, Jitao; Li, Meixian; Zhu, Zhiwei |
| 刊名 | TALANTA
 |
| 出版日期 | 2012-01-30 |
| 卷号 | 89页码:149-154 |
| 关键词 | Achiral Ionic Liquid Beta-cyclodextrin Enantioseparation Beta-blocker |
| ISSN号 | 0039-9140 |
| DOI | 10.1016/j.talanta.2011.12.005 |
| 英文摘要 | Successful simultaneous enantioseparation and sensitive determination of three beta-blockers (PIN, OX and PRO), have been achieved by capillary electrophoresis using an achiral ionic liquid, [GTMA]Cl, as a modifier to cooperate with dual CDs containing DM-beta-CD and TM-beta-CD. The influence of aIL was investigated in details, including various aILs, the concentration of aIL and molar ratio of aIL to CD. The ratio of DM-beta-CD to TM-beta-CD in dual CDs was also discussed. DM-beta-CD and TM-beta-CD favor the enantioseparations of PIN/OX and PRO, respectively. Meanwhile, the presence of [GTMA]Cl was found to play a key role in enantioseparations, and it widened the scope of application of DM-beta-CD and TM-beta-CD. Furthermore, FESI as an effective on-line sample enrichment technique was developed to improve the detection sensitivity. Under the optimum conditions, the detection limits of the three pairs of enantiomers range from 0.10 to 0.65 nM, which are much lower than those in the conventional methods. Eventually, the proposed method was successfully applied to the analysis of spiked urine sample with good recoveries. (C) 2011 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000301278000022 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48537]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhu, Zhiwei |
| 作者单位 | Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yue,Chen, Cheng,Meng, Lingchen,et al. Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives[J]. TALANTA,2012,89:149-154. |
| APA | Jin, Yue,Chen, Cheng,Meng, Lingchen,Chen, Jitao,Li, Meixian,&Zhu, Zhiwei.(2012).Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives.TALANTA,89,149-154. |
| MLA | Jin, Yue,et al."Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives".TALANTA 89(2012):149-154. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。