BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE
文献类型：期刊论文
| 作者 | Li, Cong1; Zhang, Zhe3; He, Chao-liang2; Zhuang, Xiu-li2; Chen, Li3; Cai, Qing1; Xue, Yan1; Zhang, Bin1; Wang, Shi-zhen1; Meng, Wei-yan1 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2012-07-20 |
| 期号 | 7页码:778-783 |
| 关键词 | Parathyroid Hormone Related Peptide Thermo-sensitive Hydrogel Controlled-release |
| ISSN号 | 1000-3304 |
| DOI | 10.3724/SP.J.1105.2012.12013 |
| 英文摘要 | A series of thermo-sensitive hydrogels were designed and synthesized via radical polymerization of N-isopropylacrylamide (NIPAAm) by using a biodegradable acryloyl-poly (epsilon-caprolactone)-2-hydroxylethyl methacrylate (AC-PCL-HEMA) as a cross-linker. The influence of temperature on the equilibrium swelling ratio and the optical transmittance of the hydrogel was studied. The in vitro release of parathyroid hormone related peptide (PTHrP) which can increase the number and viability of osteoblasts and promote bone formation, from the hydrogel was investigated. The release profiles indicated that the sustained release of PTHrP from the smart hydrogel was over 13 days,indicating that the materials have potential applications in the field of oral implantology. |
| 语种 | 英语 |
| WOS记录号 | WOS:000306532800014 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48595]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Cong |
| 作者单位 | 1.Jilin Univ, Sch Stomatol, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.NE Normal Univ, Coll Chem, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Cong,Zhang, Zhe,He, Chao-liang,et al. BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE[J]. ACTA POLYMERICA SINICA,2012(7):778-783. |
| APA | Li, Cong.,Zhang, Zhe.,He, Chao-liang.,Zhuang, Xiu-li.,Chen, Li.,...&Chen, Xue-si.(2012).BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE.ACTA POLYMERICA SINICA(7),778-783. |
| MLA | Li, Cong,et al."BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE".ACTA POLYMERICA SINICA .7(2012):778-783. |
入库方式： OAI收割
来源：化学研究所
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