A Multifunctional Cationic Pentathiophene: Synthesis, Organelle-Selective Imaging, and Anticancer Activity
文献类型：期刊论文
| 作者 | Yang, Gaomai; Liu, Libing; Yang, Qiong; Lv, Fengting; Wang, Shu |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2012-02-22 |
| 卷号 | 22期号:4页码:736-743 |
| 关键词 | Cationic Pentathiophene Anticancer Mitochondria Imaging Nanodrug |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201101764 |
| 英文摘要 | At present, there is an urgent necessity for the discovery of new chemotherapeutic agents with novel molecular skeleton structures that exhibit wide spectrum antitumor activity. In this work, a cationic pentathiophene (5T) is synthesized and discovered to have both anticancer activity and molecular imaging property. 5T can selectively accumulate in mitochondria to exhibit organellar imaging and efficiently induce cell apoptosis associating with JNK pathway activation. Additionally, complexes are prepared through electrostatic interactions between 5T and sodium chlorambucil (a widely used anticancer drug) with varying molar ratios. The complexes form nanoparticles in water with the size of about 50 nm. The 5T-chlorambucil nanoparticles enhance anticancer activity by 29 fold due to the synergistical anticancer activity of 5T and chlorambucil. 5T is therefore a promising multifunctional anticancer agent that incorporates optical monitoring capability and anticancer activity that targets mitochondria. |
| 语种 | 英语 |
| WOS记录号 | WOS:000300447500007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48641]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Gaomai |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Gaomai,Liu, Libing,Yang, Qiong,et al. A Multifunctional Cationic Pentathiophene: Synthesis, Organelle-Selective Imaging, and Anticancer Activity[J]. ADVANCED FUNCTIONAL MATERIALS,2012,22(4):736-743. |
| APA | Yang, Gaomai,Liu, Libing,Yang, Qiong,Lv, Fengting,&Wang, Shu.(2012).A Multifunctional Cationic Pentathiophene: Synthesis, Organelle-Selective Imaging, and Anticancer Activity.ADVANCED FUNCTIONAL MATERIALS,22(4),736-743. |
| MLA | Yang, Gaomai,et al."A Multifunctional Cationic Pentathiophene: Synthesis, Organelle-Selective Imaging, and Anticancer Activity".ADVANCED FUNCTIONAL MATERIALS 22.4(2012):736-743. |
入库方式： OAI收割
来源：化学研究所
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