New Conjugated Polymers for Photoinduced Unwinding of DNA Supercoiling and Gene Regulation
文献类型：期刊论文
| 作者 | Yang, Gaomai; Yuan, Huanxiang; Zhu, Chunlei; Liu, Libing; Yang, Qiong; Lv, Fengting; Wang, Shu |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 4期号:5页码:2334-2337 |
| 关键词 | Conjugated Polymers Reactive Oxygen Species Photoinduced Unwinding Dna Supercoiling Gene Regulation |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/am300464m |
| 英文摘要 | Three cationic polythiophene derivatives (P1, P2, P3) were synthesized and characterized. Under white light irradiation (400-800 nm), they sensitize oxygen molecule in the surrounding to generate reactive oxygen species (ROS) that can efficiently unwind the supercoiled DNA in vitro. Further study shows that this relaxation of the DNA supercoiling results in the decrease of gene (pCX-EGFP plasmid) expression level. The ability of these conjugated polymers for regulating gene expression will add a new dimension to the function of conjugated polymers. |
| 语种 | 英语 |
| WOS记录号 | WOS:000304285200006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48703]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Libing |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Gaomai,Yuan, Huanxiang,Zhu, Chunlei,et al. New Conjugated Polymers for Photoinduced Unwinding of DNA Supercoiling and Gene Regulation[J]. ACS APPLIED MATERIALS & INTERFACES,2012,4(5):2334-2337. |
| APA | Yang, Gaomai.,Yuan, Huanxiang.,Zhu, Chunlei.,Liu, Libing.,Yang, Qiong.,...&Wang, Shu.(2012).New Conjugated Polymers for Photoinduced Unwinding of DNA Supercoiling and Gene Regulation.ACS APPLIED MATERIALS & INTERFACES,4(5),2334-2337. |
| MLA | Yang, Gaomai,et al."New Conjugated Polymers for Photoinduced Unwinding of DNA Supercoiling and Gene Regulation".ACS APPLIED MATERIALS & INTERFACES 4.5(2012):2334-2337. |
入库方式： OAI收割
来源：化学研究所
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