Self-Assembly of A beta-Based Peptide Amphiphiles with Double Hydrophobic Chains
文献类型：期刊论文
| 作者 | He, Chengqian; Han, Yuchun; Fan, Yaxun; Deng, Manli; Wang, Yilin |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2012-02-21 |
| 卷号 | 28期号:7页码:3391-3396 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/la2046146 |
| 英文摘要 | Two peptide-amphiphiles (PAs), 2C(12)-Lys-A beta(12-17) and C-12-A beta(11-17)-C-12, were constructed with two alkyl chains attached to a key fragment of amyloid beta-peptide (A beta(11-17)) at different positions. The two alkyl chains of 2C(12)-Lys-A beta(12-17) were attached to the same terminus of A beta(12-17), while the two alkyl chains of C-12-A beta(11-17)-C-12 were separately attached to each terminus of A beta(11-17). The self-assembly behavior of both the PAs in aqueous solutions was studied at 25 degrees C and at pHs 3.0, 4.5, 8.5, and 11.0, focusing on the effects of the attached positions of hydrophobic chains to A beta(11-17) and the net charge quantity of the A beta(11-17) headgroup. Cryogenic transmission electron microscopy and atomic force microscopy show that 2C(12)-Lys-A beta(12-17) self-assembles into long stable fibrils over the entire pH range, while C-12-A beta(11-17)-C-12 forms short twisted ribbons and lamellae by adjusting pHs. The above fibrils, ribbons, and lamellae are generated by the lateral association of nanofibrils. Circular dichroism spectroscopy suggests the formation of beta-sheet structure with twist and disorder to different extents in the aggregates of both the PM. Some of the C-12-A beta(11-17)-C-12 molecules adopt turn conformation with the weakly charged peptide sequence, and the Fourier transform infrared spectroscopy indicates that the turn content increases with the pH increase. This work provides additional basis for the manipulations of the PA's nanostructures and will lead to the development of tunable nanostructure materials. |
| 语种 | 英语 |
| WOS记录号 | WOS:000300466200008 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48753]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Yilin |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Chengqian,Han, Yuchun,Fan, Yaxun,et al. Self-Assembly of A beta-Based Peptide Amphiphiles with Double Hydrophobic Chains[J]. LANGMUIR,2012,28(7):3391-3396. |
| APA | He, Chengqian,Han, Yuchun,Fan, Yaxun,Deng, Manli,&Wang, Yilin.(2012).Self-Assembly of A beta-Based Peptide Amphiphiles with Double Hydrophobic Chains.LANGMUIR,28(7),3391-3396. |
| MLA | He, Chengqian,et al."Self-Assembly of A beta-Based Peptide Amphiphiles with Double Hydrophobic Chains".LANGMUIR 28.7(2012):3391-3396. |
入库方式： OAI收割
来源：化学研究所
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