Biological stimuli responsive drug carriers based on keratin for triggerable drug delivery
文献类型：期刊论文
| 作者 | Li, Qinmei1,2; Zhu, Lijun1,2; Liu, Ruigang1; Huang, Da1,2; Jin, Xin1,2; Che, Ning1,2; Li, Zhuang1,2; Qu, Xiaozhong1; Kang, Hongliang1; Huang, Yong1,3 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 22期号:37页码:19964-19973 |
| ISSN号 | 0959-9428 |
| DOI | 10.1039/c2jm34136k |
| 英文摘要 | A novel drug carrier with dual triggerable release properties based on keratin graft poly(ethylene glycol) (keratin-g-PEG) copolymers is reported. Keratin-g-PEG copolymers with different graft densities are synthesized through thiol-ene click chemistry. Taking advantage of the amphiphilicity and the thiol groups of the graft copolymer, nanoparticles stabilized with PEG chains and keratin as the core, bearing glutathione (GSH) cleavable cross-links, are fabricated in aqueous solutions. The keratin-g-PEG copolymer nanoparticles can serve as excellent carriers for doxorubicin hydrochloride salt (DOX center dot HCl) with a highest loading capacity of 18.1% (w/w). The release of the loaded DOX is sensitive to the concentration of GSH, especially at a GSH concentration of cellular level. Trypsin can further trigger the release of the loaded DOX in the nanoparticles. In vitro cellular uptake experiments indicate that DOX released from the DOX-loaded keratin-g-PEG nanoparticles can be internalized into the cells efficiently, and the loaded DOX shows a faster release into the nuclei of the cells under higher GSH concentrations. The carriers have promising applications as drug carriers for intracellular drug delivery for cancer therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000308099900079 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48819]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Ruigang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Nat Res Ctr Engn Plast, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qinmei,Zhu, Lijun,Liu, Ruigang,et al. Biological stimuli responsive drug carriers based on keratin for triggerable drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(37):19964-19973. |
| APA | Li, Qinmei.,Zhu, Lijun.,Liu, Ruigang.,Huang, Da.,Jin, Xin.,...&Huang, Yong.(2012).Biological stimuli responsive drug carriers based on keratin for triggerable drug delivery.JOURNAL OF MATERIALS CHEMISTRY,22(37),19964-19973. |
| MLA | Li, Qinmei,et al."Biological stimuli responsive drug carriers based on keratin for triggerable drug delivery".JOURNAL OF MATERIALS CHEMISTRY 22.37(2012):19964-19973. |
入库方式： OAI收割
来源：化学研究所
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