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Fabrication of Gelatin Microgels by a "Cast" Strategy for Controlled Drug Release

文献类型：期刊论文

作者Wang, Anhe1; Cui, Yue2; Li, Junbai2; van Hest, Jan C. M.1
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2012-07-10
卷号22期号:13页码:2673-2681
关键词Gelatin Microgels Templating Stimulus Responsive Drug Release
ISSN号1616-301X
DOI10.1002/adfm.201102907
英文摘要In this paper, we propose a casting strategy to prepare intrinsically fluorescent, uniform and porous gelatin microgels with multi-responsiveness. Gelatin microgels with tunable size were obtained by copying the structure of a porous CaCO3 template. The diameter of the gelatin microgels was sensitive to salt concentration and pH. Doxorubicin and Rhodamine B as model drugs were loaded into the microgels via electrostatic interaction and release of the payload was triggered by changing the salt concentration and pH, respectively. Cell experiments demonstrated that the gelatin microgels had an excellent biocompatibility and biodegradability. The merits of gelatin microgels such as tunable size, biocompatibility, and stimulus responsive upload and release of positively charged small molecules will permit the microgels as excellent carriers for drug delivery. The whole manufacturing process is furthermore environmental-friendly involving no organic solvents and surfactants.
语种英语
WOS记录号WOS:000305945000002
出版者WILEY-V C H VERLAG GMBH
源URL[http://ir.iccas.ac.cn/handle/121111/48959]  
专题中国科学院化学研究所
通讯作者Wang, Anhe
作者单位1.Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands
2.Chinese Acad Sci, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Anhe,Cui, Yue,Li, Junbai,et al. Fabrication of Gelatin Microgels by a "Cast" Strategy for Controlled Drug Release[J]. ADVANCED FUNCTIONAL MATERIALS,2012,22(13):2673-2681.
APA Wang, Anhe,Cui, Yue,Li, Junbai,&van Hest, Jan C. M..(2012).Fabrication of Gelatin Microgels by a "Cast" Strategy for Controlled Drug Release.ADVANCED FUNCTIONAL MATERIALS,22(13),2673-2681.
MLA Wang, Anhe,et al."Fabrication of Gelatin Microgels by a "Cast" Strategy for Controlled Drug Release".ADVANCED FUNCTIONAL MATERIALS 22.13(2012):2673-2681.

入库方式： OAI收割

来源：化学研究所

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