Hesperetin: An inhibitor of the transforming growth factor-beta (TGF-beta) signaling pathway
文献类型：期刊论文
| 作者 | Yang, Yong1; Wolfram, Joy1; Shen, Haifa1; Fang, Xiaohong2; Ferrari, Mauro1 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 58页码:390-395 |
| 关键词 | Hesperetin Tgf-beta Inhibition Atomic Force Microscopy Single-molecule Fluorescence Imaging |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2012.10.028 |
| 英文摘要 | We have identified a previously unknown function of the natural compound, hesperetin. Here, we demonstrate that this small molecular agent is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. Single-molecule force measurements and single-molecule fluorescence imaging show that hesperetin interferes with ligand receptor interactions. Furthermore, by Western blot analysis, it was confirmed that hesperetin also inhibits the phosphorylation of Smad3, a down-stream target of the TGF-beta pathway. In addition we demonstrated that this compound hinders TGF-beta 1-induced cancer cell migration and invasion. These results suggest a potential future application for hesperetin as a TGF-beta inhibitor in cancer therapy. (C) 2012 Elsevier Masson SAS. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000312745100041 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48961]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Yong |
| 作者单位 | 1.Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA 2.Chinese Acad Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yong,Wolfram, Joy,Shen, Haifa,et al. Hesperetin: An inhibitor of the transforming growth factor-beta (TGF-beta) signaling pathway[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2012,58:390-395. |
| APA | Yang, Yong,Wolfram, Joy,Shen, Haifa,Fang, Xiaohong,&Ferrari, Mauro.(2012).Hesperetin: An inhibitor of the transforming growth factor-beta (TGF-beta) signaling pathway.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,58,390-395. |
| MLA | Yang, Yong,et al."Hesperetin: An inhibitor of the transforming growth factor-beta (TGF-beta) signaling pathway".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 58(2012):390-395. |
入库方式： OAI收割
来源：化学研究所
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