中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma

文献类型:期刊论文

作者Lu, Tiancheng1; Jing, Xiabing2; Song, Xiangfu3; Wang, Xiuran1
刊名JOURNAL OF APPLIED POLYMER SCIENCE
出版日期2012-01-05
卷号123期号:1页码:209-217
关键词Doxorubicin Peg-pla Fibers Electrospinning Drug Delivery Anticancer
ISSN号0021-8995
DOI10.1002/app.34463
英文摘要The purpose of this study was to evaluate both cytotoxicity in vitro and in vivo anticancer activities of implantable doxorubicin hydrocloride (Dox)-loaded diblock copolymer poly(ethylene glycol)-b-poly(L-lactic acid) (PEG-PLA) fiber mats (hereafter medicated mats). For in vitro evaluation, SMMC7721 cells were directly exposed to the medicated fiber mats, followed with MTT assay. For in vivo evaluation, the medicated mats were locally implanted into H22 tumor-bearing mice, followed with detection of Fas protein and flow cytometry analysis. The results showed that in vitro cytotoxicity of medicated fibers were sustained throughout the whole experiment process with the degradation of fiber matrix, while that of pure Dox was reduced in six days; medicated fibers had superior in vivo anticancer activities to pure Dox (P < 0.01). In conclusion, Doxorubicin-loaded PEG-PLA electrospun fiber mats had the properties of loading doxorubicin hydrochloride (Dox) and sustained release of Dox from medicated fiber matrix and apparently retained both in vitro cytotoxicity and in vivo anticancer activities in a long term. Medicated fiber mats are therefore suitable for a local therapy device. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 209-217, 2012
语种英语
WOS记录号WOS:000296437600023
出版者WILEY-BLACKWELL
源URL[http://ir.iccas.ac.cn/handle/121111/48987]  
专题中国科学院化学研究所
通讯作者Lu, Tiancheng
作者单位1.Jilin Agr Univ, Sch Life Sci, Changchun 130118, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, State key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
3.Jilin Univ, Sch Publ Hlth, Changchun 130022, Peoples R China
推荐引用方式
GB/T 7714
Lu, Tiancheng,Jing, Xiabing,Song, Xiangfu,et al. Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2012,123(1):209-217.
APA Lu, Tiancheng,Jing, Xiabing,Song, Xiangfu,&Wang, Xiuran.(2012).Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma.JOURNAL OF APPLIED POLYMER SCIENCE,123(1),209-217.
MLA Lu, Tiancheng,et al."Doxorubicin-Loaded Ultrafine PEG-PLA Fiber Mats Against Hepatocarcinoma".JOURNAL OF APPLIED POLYMER SCIENCE 123.1(2012):209-217.

入库方式: OAI收割

来源:化学研究所

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