Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro
文献类型：期刊论文
| 作者 | Gao, Liang; Fei, Jinbo; Zhao, Jie; Li, Hong; Cui, Yue; Li, Junbai |
| 刊名 | ACS NANO
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 6期号:9页码:8030-8040 |
| 关键词 | Gold Nanocages Photosensitizer Two-photon Photodynamic Therapy Photothermal Therapy Synergistic Effect |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/nn302634m |
| 英文摘要 | A new bioconjugate nanostructure was constructed by using photosensitizer-incorporated mixed lipid-coated gold nanocages for two-photon photothermal/photodynamic cancer therapy in vitro with high efficiency. Scanning electron microscopic and transmission electron microscopic images reveal that the precursors and bioconjugate nanostructure as-prepared are narrowly dispersed and possess uniform morphologies. The relevant energy dispersion X-ray analysis and UV-vis spectra indicate that the bioconjugate nanostructure above was assembled successfully and has a strong absorption in the near-infrared region. Fluorescence and electronic spin resonance results show that the gold nanocage in the bioconjugate nanostructure can dramatically quench the photosensitizer and inhibit the production of singlet oxygen, which is supposed to alleviate the photosensitizers' unwanted side effects originating from their nontargeted distribution. We have demonstrated that as the nanocomplex is internalized by cancer cells, under two-photon illumination, photodynamic anticancer treatment is dramatically enhanced by the photothermal effect. |
| 语种 | 英语 |
| WOS记录号 | WOS:000309040600054 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49025]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | Chinese Acad Sci, BNLMS, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Liang,Fei, Jinbo,Zhao, Jie,et al. Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro[J]. ACS NANO,2012,6(9):8030-8040. |
| APA | Gao, Liang,Fei, Jinbo,Zhao, Jie,Li, Hong,Cui, Yue,&Li, Junbai.(2012).Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro.ACS NANO,6(9),8030-8040. |
| MLA | Gao, Liang,et al."Hypocrellin-Loaded Gold Nanocages with High Two-Photon Efficiency for Photothermal/Photodynamic Cancer Therapy in Vitro".ACS NANO 6.9(2012):8030-8040. |
入库方式： OAI收割
来源：化学研究所
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