Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery
文献类型：期刊论文
| 作者 | Zhou, Dongfang2; Xiao, Haihua2; Meng, Fanbo1; Zhou, Shaoyang3; Guo, Jinshan2; Li, Xiaoyuan2; Jing, Xiabin2; Huang, Yubin2 |
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2012-12-01 |
| 卷号 | 23期号:12页码:2335-2343 |
| ISSN号 | 1043-1802 |
| DOI | 10.1021/bc300144e |
| 英文摘要 | Platinum(IV), a pro-drug of platinum(II), was conjugated to poly(L-lysine) (PLL), and then assembled with poly(glutamic acid) (PGA) through a layer-by-layer (LbL) approach on colloidal silica templates. After removal of the templates, biodegradable PGA/PLL-Pt(IV) multilayer capsules (diameter = 0.5 mu m) with 10 mu g of platinum incorporated into each bilayer were obtained. Under acidic and/or reductive conditions, the amount and rate of platinum released from the capsules were increased, which are desirable traits for platinum-based anticancer drug delivery systems. Furthermore, in vitro evaluation showed that the PGA/PLL-Pt(IV) multilayer microcapsule's displayed higher cytotoxicity (IC50Pt = 3.5 mu g/mL) against colon cancer cells CT-26 than that of free cisplatin (IC50Pt = 8.6 mu g/mL). This enhanced cytotoxicity was attributed to the effective internalization of the capsules by the cancer cells, which was observed by confocal laser scanning microscopy (CLSM) imaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000312429900003 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49113]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Meng, Fanbo |
| 作者单位 | 1.Jilin Univ, China Japan Union Hosp, Dept Cardiol, Changchun 130033, Peoples R China 2.Chinese Acad Sci, Grad Sch, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.NE Normal Univ, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Dongfang,Xiao, Haihua,Meng, Fanbo,et al. Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery[J]. BIOCONJUGATE CHEMISTRY,2012,23(12):2335-2343. |
| APA | Zhou, Dongfang.,Xiao, Haihua.,Meng, Fanbo.,Zhou, Shaoyang.,Guo, Jinshan.,...&Huang, Yubin.(2012).Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery.BIOCONJUGATE CHEMISTRY,23(12),2335-2343. |
| MLA | Zhou, Dongfang,et al."Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery".BIOCONJUGATE CHEMISTRY 23.12(2012):2335-2343. |
入库方式： OAI收割
来源：化学研究所
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