Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure
文献类型：期刊论文
| 作者 | Yang, Sheng-Tao1,2; Wang, Tiancheng3; Dong, Erya2; Chen, Xin-Xin2; Xiang, Kun2; Liu, Jia-Hui2,4; Liu, Yuanfang2,4; Wang, Haifang2 |
| 刊名 | TOXICOLOGY RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 1期号:1页码:69-74 |
| ISSN号 | 2045-452X |
| DOI | 10.1039/c2tx20008b |
| 英文摘要 | Alumina nanoparticles (NPs) are among the most important nanomaterials and are widely used in diverse areas. In this study, we evaluated the bioavailability and toxicity of alumina NPs in mice after oral exposure, compared with traditional alumina powder. Our results indicated that negligible alumina NPs were absorbed post-exposure and alumina NPs did not influence the balance of essential trace elements, including Fe, Cu and Zn. Preliminary toxicological evaluations suggested that alumina NPs were of low toxicity. The body weights were similar among the mice exposed to alumina NPs, alumina powder and 0.9% NaCl aqueous solution. The low toxicity was also indicated by the unchanged serum biochemical parameters. The implications related to the ongoing safety evaluations and applications of alumina NPs are discussed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315731500009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49117]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Sheng-Tao |
| 作者单位 | 1.Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China 2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China 3.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China 4.Peking Univ, Beijing Natl Lab Mol Sci, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Sheng-Tao,Wang, Tiancheng,Dong, Erya,et al. Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure[J]. TOXICOLOGY RESEARCH,2012,1(1):69-74. |
| APA | Yang, Sheng-Tao.,Wang, Tiancheng.,Dong, Erya.,Chen, Xin-Xin.,Xiang, Kun.,...&Wang, Haifang.(2012).Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure.TOXICOLOGY RESEARCH,1(1),69-74. |
| MLA | Yang, Sheng-Tao,et al."Bioavailability and preliminary toxicity evaluations of alumina nanoparticles in vivo after oral exposure".TOXICOLOGY RESEARCH 1.1(2012):69-74. |
入库方式： OAI收割
来源：化学研究所
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