Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery
文献类型：期刊论文
| 作者 | Song, Wantong1,2; Tang, Zhaohui1; Li, Mingqiang1,2; Lv, Shixian1,2; Yu, Haiyang1; Ma, Lili1; Zhuang, Xiuli1; Huang, Yubin3; Chen, Xuesi1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 12期号:10页码:1375-1383 |
| 关键词 | Drug Delivery Systems Intracellular Targeting Micelles Poly(Ss-amino Ester) Stimuli-sensitive Polymers |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201200122 |
| 英文摘要 | The pH sensitivity of a series of PbAEs synthesized from primary amines and diacrylates is studied. By changing alkyl groups of the amine monomers, the pKb can be tuned across a broad range (from 3.5 to 7.2). Micelles formed from a PEG-PbAE block copolymer retain the pH sensitivity of PbAE and can stably load hydrophobic molecules under neutral pH, while quickly dissociate and release their cargoes at pH similar to 6.0. When the chemotherapy drug DOX is loaded, the micelles show efficient cell proliferation inhibition to HeLa cells and fast intracellular release. Thus, the primary-amine-based PbAEs are shown to be promising in the construction of intracellular targeting drug delivery systems. |
| 语种 | 英语 |
| WOS记录号 | WOS:000309676400011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49291]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Wantong,Tang, Zhaohui,Li, Mingqiang,et al. Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery[J]. MACROMOLECULAR BIOSCIENCE,2012,12(10):1375-1383. |
| APA | Song, Wantong.,Tang, Zhaohui.,Li, Mingqiang.,Lv, Shixian.,Yu, Haiyang.,...&Chen, Xuesi.(2012).Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery.MACROMOLECULAR BIOSCIENCE,12(10),1375-1383. |
| MLA | Song, Wantong,et al."Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery".MACROMOLECULAR BIOSCIENCE 12.10(2012):1375-1383. |
入库方式： OAI收割
来源：化学研究所
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