A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups
文献类型：期刊论文
| 作者 | Xiao, Haihua1,2; Zhou, Dongfang1,2; Liu, Shi1; Zheng, Yonghui1; Huang, Yubin1; Jing, Xiabin1 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 8期号:5页码:1859-1868 |
| 关键词 | Cancers Micelles Oxaliplatin Polymer-drug Conjugate Pro-drug |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2012.01.007 |
| 英文摘要 | A biodegradable and amphiphilic copolymer, MPEG-b-P(LA-co-MCC), which contains pendant carboxyl groups, was chosen as a drug carrier for the active anticancer part (DACH-Pt) of oxaliplatin to form an MPEG-b-P(LA-co-MCC/Pt) complex. It was able to self-assemble into micelles with a mean diameter of 30-40 nm, and a surface potential near -10 mV. The typical platinum content was 10 wt.%. The micelles showed acid-responsive drug release kinetics, which is beneficial for drug release in the intracellular environment. The Pt(II) species were released mainly in the form of DACH-Pt-Cl-2 in 150 mM NaCl solution and DACH-Pt2+-(H2O)(2) in pure water according to the results obtained by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry and X-ray photoelectron spectroscopy. In vitro evaluation showed that the micelles displayed the same or higher cytotoxicities against SKOV-3, HeLa, and EC-109 cancer cells compared with oxaliplatin. The enhanced cytotoxicity against SKOV-3 cells is attributed to effective internalization of the micelles by the cells via endocytosis and the sensitivity of SKOV-3 cells to platinum drugs. This novel biodegradable and amphiphilic copolymer-based platinum drug will have great potential application in clinical use. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000302989700020 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/49417]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Jing, Xiabin |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Haihua,Zhou, Dongfang,Liu, Shi,et al. A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups[J]. ACTA BIOMATERIALIA,2012,8(5):1859-1868. |
| APA | Xiao, Haihua,Zhou, Dongfang,Liu, Shi,Zheng, Yonghui,Huang, Yubin,&Jing, Xiabin.(2012).A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups.ACTA BIOMATERIALIA,8(5),1859-1868. |
| MLA | Xiao, Haihua,et al."A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups".ACTA BIOMATERIALIA 8.5(2012):1859-1868. |
入库方式： OAI收割
来源：化学研究所
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